Immunosignaturing: A critical review

Kathryn F. Sykes, Joseph B. Legutki, Phillip Stafford

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Health is a complex interaction between metabolism, physiology, and immunity. Although it is difficult to define quantitatively, the activity of the humoral immune system provides a reasonable proxy for changes in health. Immunosignaturing is a microarray-based technology that quantitates the dynamics of circulating antibodies. Recent advancements in the field warrant a review of the technology. Here, we provide an introduction to the technique, evaluate the current progress, contrast similar technologies, and suggest applications that immunosignaturing could facilitate.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalTrends in Biotechnology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Antibody profiling
  • Biomarker discovery
  • Health monitoring
  • Immunodiagnostics
  • Peptide microarray

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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    Sykes, K. F., Legutki, J. B., & Stafford, P. (2013). Immunosignaturing: A critical review. Trends in Biotechnology, 31(1), 45-51. https://doi.org/10.1016/j.tibtech.2012.10.012