Immunosignature differentiation of non-infectious meningoencephalomyelitis and intracranial neoplasia in dogs

Bathilda B. Lake, John Henry Rossmeisl, Julie Cecere, Phillip Stafford, Kurt L. Zimmerman

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A variety of inflammatory conditions of unknown cause (meningoencephalomyelitis of unknown etiology-MUE) and neoplastic diseases can affect the central nervous system (CNS) of dogs. MUE can mimic intracranial neoplasia both clinically, radiologically and even in some cases, histologically. Serum immunosignature protein microarray assays have been used in humans to identify CNS diseases such as Alzheimer's and neoplasia, and in dogs, to detect lymphoma and its progression. This study evaluated the effectiveness of immunosignature profiles for distinguishing between three cohorts of dogs: healthy, intracranial neoplasia, and MUE. Using the learned peptide patterns for these three cohorts, classification prediction was evaluated for the same groups using a 10-fold cross validation methodology. Accuracy for classification was 100%, as well as 100% specific and 100% sensitive. This pilot study demonstrates that immunosignature profiles may help serve as a minimally invasive tool to distinguish between MUE and intracranial neoplasia in dogs.

Original languageEnglish (US)
Article number97
JournalFrontiers in Veterinary Science
Volume5
Issue numberMAY
DOIs
StatePublished - May 11 2018

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Keywords

  • Canine
  • Immunosignature
  • Intracranial neoplasia
  • Meningoencephalomyelitis of unknown etiology
  • Peptide microarray

ASJC Scopus subject areas

  • veterinary(all)

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