Immunomodulatory proteins of myxoma virus

John W. Barrett, Jing Xin Cao, Sheela Hota-Mitchell, Grant McFadden

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Poxviruses collectively encode an impressive collection of diverse immunomodulatory proteins. In this review we draw attention to some of the new open reading frames (ORFs) discovered during the sequencing of the myxoma virus DNA genome [Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao J-X, Macaulay C, Willer D, Evans D, McFadden G (1999) The complete DNA sequence of myxoma virus. Virology 264:298-318] that may function to subvert the host immune system. Most of these predicted functions are speculative but some of the deduced primary amino acid sequences contain intriguing similarities to known cellular and viral proteins in the public domain for which immunomodulatory functions have been assigned.

Original languageEnglish (US)
Pages (from-to)73-84
Number of pages12
JournalSeminars in Immunology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Immunomodulators
  • Myxoma virus
  • Poxvirus
  • Viroceptors
  • Virokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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