Immunomodulatory proteins of myxoma virus

John W. Barrett, Jing Xin Cao, Sheela Hota-Mitchell, Douglas McFadden

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Poxviruses collectively encode an impressive collection of diverse immunomodulatory proteins. In this review we draw attention to some of the new open reading frames (ORFs) discovered during the sequencing of the myxoma virus DNA genome [Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao J-X, Macaulay C, Willer D, Evans D, McFadden G (1999) The complete DNA sequence of myxoma virus. Virology 264:298-318] that may function to subvert the host immune system. Most of these predicted functions are speculative but some of the deduced primary amino acid sequences contain intriguing similarities to known cellular and viral proteins in the public domain for which immunomodulatory functions have been assigned.

Original languageEnglish (US)
Pages (from-to)73-84
Number of pages12
JournalSeminars in Immunology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Myxoma virus
Poxviridae
Virology
Public Sector
Viral Proteins
Open Reading Frames
Amino Acid Sequence
Immune System
Proteins
Genome
DNA

Keywords

  • Immunomodulators
  • Myxoma virus
  • Poxvirus
  • Viroceptors
  • Virokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunomodulatory proteins of myxoma virus. / Barrett, John W.; Cao, Jing Xin; Hota-Mitchell, Sheela; McFadden, Douglas.

In: Seminars in Immunology, Vol. 13, No. 1, 01.01.2001, p. 73-84.

Research output: Contribution to journalReview article

Barrett, JW, Cao, JX, Hota-Mitchell, S & McFadden, D 2001, 'Immunomodulatory proteins of myxoma virus', Seminars in Immunology, vol. 13, no. 1, pp. 73-84. https://doi.org/10.1006/smim.2000.0298
Barrett, John W. ; Cao, Jing Xin ; Hota-Mitchell, Sheela ; McFadden, Douglas. / Immunomodulatory proteins of myxoma virus. In: Seminars in Immunology. 2001 ; Vol. 13, No. 1. pp. 73-84.
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