TY - GEN
T1 - Immunomodulatory biomaterials to improve allogeneic islet graft survival in a murine diabetic model
AU - Coronel, M. M.
AU - Weaver, J.
AU - Hunckler, M.
AU - Yolcu, E.
AU - Shirwan, H.
AU - García, A. J.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Type 1 diabetes (T1D) is a chronic condition in which patients produce little to no insulin due to the autoimmune progressive loss of beta cells. Whereas the disease can be managed via external insulin delivery, patients still experience a high incidence of mortality and chronic debilitating comorbidities. Islet transplantation has emerged as a potential strategy to restore a patient’s glycemic control, yet long-term rejection and the need for chronic immunosuppression present a major barrier. Herein, we engineered a synthetic material to provide biological cues locally and in a controlled manner to enhance vascularization and promote long-term islet graft survival.
AB - Statement of Purpose: Type 1 diabetes (T1D) is a chronic condition in which patients produce little to no insulin due to the autoimmune progressive loss of beta cells. Whereas the disease can be managed via external insulin delivery, patients still experience a high incidence of mortality and chronic debilitating comorbidities. Islet transplantation has emerged as a potential strategy to restore a patient’s glycemic control, yet long-term rejection and the need for chronic immunosuppression present a major barrier. Herein, we engineered a synthetic material to provide biological cues locally and in a controlled manner to enhance vascularization and promote long-term islet graft survival.
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M3 - Conference contribution
AN - SCOPUS:85065403685
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 235
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -