Immunomodulatory biomaterials to improve allogeneic islet graft survival in a murine diabetic model

M. M. Coronel, J. Weaver, M. Hunckler, E. Yolcu, H. Shirwan, A. J. García

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Type 1 diabetes (T1D) is a chronic condition in which patients produce little to no insulin due to the autoimmune progressive loss of beta cells. Whereas the disease can be managed via external insulin delivery, patients still experience a high incidence of mortality and chronic debilitating comorbidities. Islet transplantation has emerged as a potential strategy to restore a patient’s glycemic control, yet long-term rejection and the need for chronic immunosuppression present a major barrier. Herein, we engineered a synthetic material to provide biological cues locally and in a controlled manner to enhance vascularization and promote long-term islet graft survival.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Coronel, M. M., Weaver, J., Hunckler, M., Yolcu, E., Shirwan, H., & García, A. J. (2019). Immunomodulatory biomaterials to improve allogeneic islet graft survival in a murine diabetic model. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.