Abstract
The effect of the sulfhydryl inhibitor iodoacetate and of iodoacetate-treated thymocytes from leukemic AKR mice (ITC) on the humoral immune response of preleukemic AKR mice (8 or 12 weeks old) to sheep erythrocytes (SRBC) was assessed. Six days after a single injection of iodoacetate or ITC (viable or nonviable), mice were administered SRBC, and their spleens and thymuses assayed for total number of plaque-forming cells (PFC) four days later. Histopathologic studies also were performed on samplings of mice from all test and control groups. Significant increases in total numbers of splenic PFC were noted in mice given either iodoacetate or viable ITC. Histopathologic examination of the spleens of AKR mice from these two groups revealed large numbers of mature lymphoid cells in the red pulp areas. The IgG response was absent in mice administered ITC (viable or nonviable).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-352 |
| Number of pages | 10 |
| Journal | Immunological Investigations |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Immunologic responsiveness of Young AKR mice to iodoacetate and to iodoacetate-treated tumor cells. / Barker, Anna; Rheins, M. S.; Davis, G. W.; Wilson, H. E.
In: Immunological Investigations, Vol. 2, No. 4, 1973, p. 343-352.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunologic responsiveness of Young AKR mice to iodoacetate and to iodoacetate-treated tumor cells
AU - Barker, Anna
AU - Rheins, M. S.
AU - Davis, G. W.
AU - Wilson, H. E.
PY - 1973
Y1 - 1973
N2 - The effect of the sulfhydryl inhibitor iodoacetate and of iodoacetate-treated thymocytes from leukemic AKR mice (ITC) on the humoral immune response of preleukemic AKR mice (8 or 12 weeks old) to sheep erythrocytes (SRBC) was assessed. Six days after a single injection of iodoacetate or ITC (viable or nonviable), mice were administered SRBC, and their spleens and thymuses assayed for total number of plaque-forming cells (PFC) four days later. Histopathologic studies also were performed on samplings of mice from all test and control groups. Significant increases in total numbers of splenic PFC were noted in mice given either iodoacetate or viable ITC. Histopathologic examination of the spleens of AKR mice from these two groups revealed large numbers of mature lymphoid cells in the red pulp areas. The IgG response was absent in mice administered ITC (viable or nonviable).
AB - The effect of the sulfhydryl inhibitor iodoacetate and of iodoacetate-treated thymocytes from leukemic AKR mice (ITC) on the humoral immune response of preleukemic AKR mice (8 or 12 weeks old) to sheep erythrocytes (SRBC) was assessed. Six days after a single injection of iodoacetate or ITC (viable or nonviable), mice were administered SRBC, and their spleens and thymuses assayed for total number of plaque-forming cells (PFC) four days later. Histopathologic studies also were performed on samplings of mice from all test and control groups. Significant increases in total numbers of splenic PFC were noted in mice given either iodoacetate or viable ITC. Histopathologic examination of the spleens of AKR mice from these two groups revealed large numbers of mature lymphoid cells in the red pulp areas. The IgG response was absent in mice administered ITC (viable or nonviable).
UR - http://www.scopus.com/inward/record.url?scp=84907111483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907111483&partnerID=8YFLogxK
U2 - 10.3109/08820137309022805
DO - 10.3109/08820137309022805
M3 - Article
C2 - 4583065
AN - SCOPUS:84907111483
VL - 2
SP - 343
EP - 352
JO - Immunological Investigations
JF - Immunological Investigations
SN - 0882-0139
IS - 4
ER -