Immunohistochemical studies of blood group substance h in colorectal tumors using a monoclonal antibody

Carolyn Compton, Richard Wyatt, Angelyn Konugres, Deborah Ehrenthal, Paul Durda

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas studied were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree of dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions. Cancer 59:118–127, 1987.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalCancer
Volume59
Issue number1
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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