Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules

Andrei I. Chapoval, Gefeng Zhu, Lieping Chen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Costimulatory signal(s) in addition to engagement of T cell receptor is important for optimal activation of T lymphocytes. During last decade several dozens of new costimulatory molecules, including 4-1BB, CD40, OX40, CD27, and ICOS, have been identified. It is likely that in Post-Genome Era more molecules with potential costimulatory properties will be brought to our attention. We describe here a simple and reliable strategy for evaluating the functional activities of potential costimulatory molecules using soluble fusion protein between extracellular portion of costimulatory ligand and Fc portion of mouse IgG2a.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalApplied Biochemistry and Biotechnology - Part B Molecular Biotechnology
Volume21
Issue number3
DOIs
StatePublished - Jul 4 2002
Externally publishedYes

Keywords

  • Costimulation
  • Fusion protein
  • T lymphocytes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology

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