Abstract
Immunization using genetic expression libraries may be an improvement over conventional DNA immunization using a single gene because more epitopes are simultaneously presented to the immune system. In this study, we evaluated the effectiveness of an HIV-2 vaccine made from a genomic expression library in baboons. We found that HIV-2 expression library immunization induced HIV-2-specific memory responses but low levels of CD8+ cell anti-viral responses and neutralizing antibodies. After intravenous virus challenge using a homologous pathogenic variant, HIV-2UC2/9429, viral loads were similar in the HIV-2-immunized and control baboons. We conclude that although immunization using HIV-2 expression libraries induces immune responses, this approach does not provide protection in baboons against intravenous challenge with HIV-2.
Original language | English (US) |
---|---|
Pages (from-to) | 323-329 |
Number of pages | 7 |
Journal | Journal of Medical Primatology |
Volume | 31 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2002 |
Externally published | Yes |
Keywords
- AIDS
- DNA vaccine
- Expression library immunization
- Gene immunization
- Papio
ASJC Scopus subject areas
- Animal Science and Zoology
- General Veterinary