Immune responses in baboons vaccinated with HIV-2 genetic expression libraries

Christopher P. Locher, K. F. Sykes, D. J. Blackbourn, S. A. Johnston

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Immunization using genetic expression libraries may be an improvement over conventional DNA immunization using a single gene because more epitopes are simultaneously presented to the immune system. In this study, we evaluated the effectiveness of an HIV-2 vaccine made from a genomic expression library in baboons. We found that HIV-2 expression library immunization induced HIV-2-specific memory responses but low levels of CD8+ cell anti-viral responses and neutralizing antibodies. After intravenous virus challenge using a homologous pathogenic variant, HIV-2UC2/9429, viral loads were similar in the HIV-2-immunized and control baboons. We conclude that although immunization using HIV-2 expression libraries induces immune responses, this approach does not provide protection in baboons against intravenous challenge with HIV-2.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalJournal of Medical Primatology
Volume31
Issue number6
DOIs
StatePublished - Dec 2002

Keywords

  • AIDS
  • DNA vaccine
  • Expression library immunization
  • Gene immunization
  • Papio

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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