Images of the DNA double helix in water

Stuart Lindsay; T. Thundat; L. Nagahara; U. Knipping; R. L. Rill

doi:10.1126/science.2727694

Images of the DNA double helix in water

Stuart Lindsay, T. Thundat, L. Nagahara, U. Knipping, R. L. Rill

Physics

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

The scanning tunneling microscope can image uncoated DNA submerged in water. The grooves of the double helix were clearly resolved in images of the 146-base pair fragment extracted from calf thymus nucleosome. In contrast to images obtained with dry DNA, the helix pitch varied only a small amount (36±5 angstroms). The path of the helix shows considerable variation. It is quite straight when the molecules are densely packed, but it curves and bends in isolated molecules.

Original language	English (US)
Pages (from-to)	1063-1064
Number of pages	2
Journal	Science
Volume	244
Issue number	4908
DOIs	https://doi.org/10.1126/science.2727694
State	Published - 1989

ASJC Scopus subject areas

General

Access to Document

10.1126/science.2727694

Cite this

@article{31f8c77cc4374389a69e3a51d39a01bb,

title = "Images of the DNA double helix in water",

abstract = "The scanning tunneling microscope can image uncoated DNA submerged in water. The grooves of the double helix were clearly resolved in images of the 146-base pair fragment extracted from calf thymus nucleosome. In contrast to images obtained with dry DNA, the helix pitch varied only a small amount (36±5 angstroms). The path of the helix shows considerable variation. It is quite straight when the molecules are densely packed, but it curves and bends in isolated molecules.",

author = "Stuart Lindsay and T. Thundat and L. Nagahara and U. Knipping and Rill, {R. L.}",

year = "1989",

doi = "10.1126/science.2727694",

language = "English (US)",

volume = "244",

pages = "1063--1064",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4908",

}

TY - JOUR

T1 - Images of the DNA double helix in water

AU - Lindsay, Stuart

AU - Thundat, T.

AU - Nagahara, L.

AU - Knipping, U.

AU - Rill, R. L.

PY - 1989

Y1 - 1989

N2 - The scanning tunneling microscope can image uncoated DNA submerged in water. The grooves of the double helix were clearly resolved in images of the 146-base pair fragment extracted from calf thymus nucleosome. In contrast to images obtained with dry DNA, the helix pitch varied only a small amount (36±5 angstroms). The path of the helix shows considerable variation. It is quite straight when the molecules are densely packed, but it curves and bends in isolated molecules.

AB - The scanning tunneling microscope can image uncoated DNA submerged in water. The grooves of the double helix were clearly resolved in images of the 146-base pair fragment extracted from calf thymus nucleosome. In contrast to images obtained with dry DNA, the helix pitch varied only a small amount (36±5 angstroms). The path of the helix shows considerable variation. It is quite straight when the molecules are densely packed, but it curves and bends in isolated molecules.

UR - http://www.scopus.com/inward/record.url?scp=0024384378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024384378&partnerID=8YFLogxK

U2 - 10.1126/science.2727694

DO - 10.1126/science.2727694

M3 - Article

C2 - 2727694

AN - SCOPUS:0024384378

SN - 0036-8075

VL - 244

SP - 1063

EP - 1064

JO - Science

JF - Science

IS - 4908

ER -

Images of the DNA double helix in water

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this