Identifying effective and feasible interventions to accelerate functional recovery from hospitalization in older adults: A randomized controlled pilot trial

Rachel R. Deer, Jared Dickinson, Steve R. Fisher, Hyunsu Ju, Elena Volpi

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Hospitalization induces functional decline in older adults. Many geriatric patients fail to fully recover physical function after hospitalization, which increases the risk of frailty, disability, dependence, re-hospitalization, and mortality. There is a lack of evidence-based therapies that can be implemented following hospitalization to accelerate functional improvements. The aims of this Phase I clinical trial are to determine 1) the effect size and variability of targeted interventions in accelerating functional recovery from hospitalization and 2) the feasibility of implementing such interventions in community-dwelling older adults. Older patients (≥. 65 years, n = 100) will be recruited from a single site during hospitalization for an acute medical condition. Subjects will be randomized to one of five interventions initiated immediately upon discharge: 1. protein supplementation, 2. in-home rehabilitation plus placebo supplementation, 3. in-home rehabilitation plus protein supplementation, 4. single testosterone injection, or 5. isocaloric placebo supplementation. Testing will occur during hospitalization (baseline) and at 1 and 4 weeks post-discharge. Each testing session will include measures of muscle strength, physical function/performance, body composition, and psychological function. Physical activity levels will be continuously monitored throughout study participation. Feasibility will be determined through collection of the number of eligible, contacted, and enrolled patients; intervention adherence and compliance; and reasons for declining enrollment and study withdrawal. This research will determine the feasibility of post-hospitalization strategies to improve physical function in older adults. These results will also provide a foundation for performing larger, multi-site clinical trials to improve physical function and reduce readmissions in geriatric patents.

    Original languageEnglish (US)
    Pages (from-to)6-14
    Number of pages9
    JournalContemporary Clinical Trials
    Volume49
    DOIs
    StatePublished - Jul 1 2016

    Fingerprint

    Hospitalization
    Randomized Controlled Trials
    Geriatrics
    Rehabilitation
    Placebos
    Independent Living
    Clinical Trials, Phase I
    Patents
    Muscle Strength
    Body Composition
    Compliance
    Testosterone
    Proteins
    Clinical Trials
    Exercise
    Psychology
    Injections
    Mortality
    Research

    Keywords

    • Exercise
    • Geriatrics
    • Hospitalization
    • Physical function
    • Protein
    • Testosterone

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Medicine(all)

    Cite this

    Identifying effective and feasible interventions to accelerate functional recovery from hospitalization in older adults : A randomized controlled pilot trial. / Deer, Rachel R.; Dickinson, Jared; Fisher, Steve R.; Ju, Hyunsu; Volpi, Elena.

    In: Contemporary Clinical Trials, Vol. 49, 01.07.2016, p. 6-14.

    Research output: Contribution to journalArticle

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