Identification of DNA basepairing via tunnel-current decay

Jin He; Lisha Lin; Peiming Zhang; Stuart Lindsay

doi:10.1021/nl0726205

Identification of DNA basepairing via tunnel-current decay

Jin He, Lisha Lin, Peiming Zhang, Stuart Lindsay

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond- mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.

Original language	English (US)
Pages (from-to)	3854-3858
Number of pages	5
Journal	Nano Letters
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/nl0726205
State	Published - Dec 2007

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl0726205

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abstract = "We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond- mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.",

author = "Jin He and Lisha Lin and Peiming Zhang and Stuart Lindsay",

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Identification of DNA basepairing via tunnel-current decay

Abstract

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