68 Citations (Scopus)

Abstract

We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond- mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.

Original languageEnglish (US)
Pages (from-to)3854-3858
Number of pages5
JournalNano Letters
Volume7
Issue number12
DOIs
StatePublished - Dec 2007

Fingerprint

tunnels
Tunnels
DNA
deoxyribonucleic acid
Electrodes
nucleosides
Nanopores
electrodes
decay
Nucleosides
Monolayers
Hydrogen bonds
hydrogen bonds
Molecules
probes
molecules
interactions

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Identification of DNA basepairing via tunnel-current decay. / He, Jin; Lin, Lisha; Zhang, Peiming; Lindsay, Stuart.

In: Nano Letters, Vol. 7, No. 12, 12.2007, p. 3854-3858.

Research output: Contribution to journalArticle

He, Jin ; Lin, Lisha ; Zhang, Peiming ; Lindsay, Stuart. / Identification of DNA basepairing via tunnel-current decay. In: Nano Letters. 2007 ; Vol. 7, No. 12. pp. 3854-3858.
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