Identification of botanicals with potential therapeutic use against methicillin-resistant Staphylococcus aureus (MRSA) infections

Johanne Gerstel, Tiffany Turner, Guillermo Ruiz, Justin Wise, Ashley Stein, Greg Jones, Tanya Morin, Tony Pinazza, Elena Sukhorukov, Donna Clark, Taelor Steen, Berlin Wright, Jeffrey Langland

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Staphylococcus aureus is an opportunistic pathogen. Over- and improper-use of pharmaceuticals against S. aureus has led to the development of antibiotic resistance, including methicillin-resistant S. aureus (MRSA). This study examined the efficacy of botanical extracts as an alternative form of treatment to S. aureus and MRSA, including penicillin/methicillin-resistant S. aureus (PenR), and multidrug resistant S. aureus (MDR). Initial screening of botanicals was done via a minimum inhibitory concentration procedure. In addition, a temporal growth curve was performed in order to quantify the growth of the bacteria in the presence of the extracts. Results demonstrated 13 botanicals that had varying activities against S. aureus, PenR, and MDR. These botanicals were separated into mild, moderate, and highly efficacious based on the concentration needed to inhibit bacterial growth. These results propose a comparison of botanical-derived antimicrobial extracts that may be utilized against S. aureus and different antibiotic resistant strains of MRSA.

Original languageEnglish (US)
Pages (from-to)2577-2585
Number of pages9
JournalPhytotherapy Research
Volume32
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • MRSA
  • Staphylococcus aureus
  • antibiotic resistance
  • botanical
  • tincture

ASJC Scopus subject areas

  • Pharmacology

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