Identification and in silico characterisation of defective molecules associated with isolates of banana bunchy top virus

Daisy Stainton; Darren P. Martin; David A. Collings; John E. Thomas; Arvind Varsani

doi:10.1007/s00705-015-2736-0

Identification and in silico characterisation of defective molecules associated with isolates of banana bunchy top virus

Daisy Stainton, Darren P. Martin, David A. Collings, John E. Thomas, Arvind Varsani

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Banana bunchy top virus (BBTV) is a multi-component single-stranded DNA virus. From 267 potentially infected Musa plants, 24 apparently ‘defective’ BBTV components have been identified. Interestingly, 23/24 of these defective molecules were apparently derived from DNA-R. All of the identified defective molecules had retained at least part of the CR-SL and CR-M but had insertions and/or deletions that in most cases resulted in open reading frame disruptions. Our detection of three monophyletic but diverse (and therefore likely circulating) defective DNA-R lineages suggests that, in many cases, defective DNA-R molecules might remain associated with BBTV genomes for prolonged periods.

Original language	English (US)
Pages (from-to)	1019-1026
Number of pages	8
Journal	Archives of Virology
Volume	161
Issue number	4
DOIs	https://doi.org/10.1007/s00705-015-2736-0
State	Published - Apr 1 2016
Externally published	Yes

Keywords

Banana bunchy top virus
Defective molecules
Nanovirus

ASJC Scopus subject areas

General Medicine
Virology

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10.1007/s00705-015-2736-0

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title = "Identification and in silico characterisation of defective molecules associated with isolates of banana bunchy top virus",

abstract = "Banana bunchy top virus (BBTV) is a multi-component single-stranded DNA virus. From 267 potentially infected Musa plants, 24 apparently {\textquoteleft}defective{\textquoteright} BBTV components have been identified. Interestingly, 23/24 of these defective molecules were apparently derived from DNA-R. All of the identified defective molecules had retained at least part of the CR-SL and CR-M but had insertions and/or deletions that in most cases resulted in open reading frame disruptions. Our detection of three monophyletic but diverse (and therefore likely circulating) defective DNA-R lineages suggests that, in many cases, defective DNA-R molecules might remain associated with BBTV genomes for prolonged periods.",

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T1 - Identification and in silico characterisation of defective molecules associated with isolates of banana bunchy top virus

AU - Stainton, Daisy

AU - Martin, Darren P.

AU - Collings, David A.

AU - Thomas, John E.

AU - Varsani, Arvind

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Banana bunchy top virus (BBTV) is a multi-component single-stranded DNA virus. From 267 potentially infected Musa plants, 24 apparently ‘defective’ BBTV components have been identified. Interestingly, 23/24 of these defective molecules were apparently derived from DNA-R. All of the identified defective molecules had retained at least part of the CR-SL and CR-M but had insertions and/or deletions that in most cases resulted in open reading frame disruptions. Our detection of three monophyletic but diverse (and therefore likely circulating) defective DNA-R lineages suggests that, in many cases, defective DNA-R molecules might remain associated with BBTV genomes for prolonged periods.

AB - Banana bunchy top virus (BBTV) is a multi-component single-stranded DNA virus. From 267 potentially infected Musa plants, 24 apparently ‘defective’ BBTV components have been identified. Interestingly, 23/24 of these defective molecules were apparently derived from DNA-R. All of the identified defective molecules had retained at least part of the CR-SL and CR-M but had insertions and/or deletions that in most cases resulted in open reading frame disruptions. Our detection of three monophyletic but diverse (and therefore likely circulating) defective DNA-R lineages suggests that, in many cases, defective DNA-R molecules might remain associated with BBTV genomes for prolonged periods.

KW - Banana bunchy top virus

KW - Defective molecules

KW - Nanovirus

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Identification and in silico characterisation of defective molecules associated with isolates of banana bunchy top virus

Abstract

Keywords

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