IBDV-induced bursal T lymphocytes inhibit mitogenic response of normal splenocytes

In Jeong Kim, Jagdev M. Sharma

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We examined the suppressive activity of bursal T cells induced by infectious bursal disease virus (IBDV) in inbred (15x7) and outbred commercial specific-pathogen-free (SPF) chickens. The suppressive activity was measured by the ability of bursal and splenic T cells from IBDV-infected chickens to inhibit mitogenic responses of normal splenocytes. The bursacytes but not the splenocytes of IBDV-infected chickens inhibited the mitogenic responses of normal splenocytes. The mitogenic inhibition by the bursacytes of IBDV-infected chickens was dose-dependent. The suppression was observed both in inbred and non-inbred chickens, and thus, was non MHC-restricted. Cell-sorting experiments revealed that both CD4+ and CD8+ cells from the bursa of IBDV-infected chickens, as well as cell-culture supernatants conditioned by these cells, mediated suppression. Suppressor T (Ts) cells may therefore be involved in the immunosuppression induced by IBDV. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalVeterinary Immunology and Immunopathology
Volume74
Issue number1-2
DOIs
StatePublished - Apr 19 2000

Keywords

  • Bursa of Fabricius
  • IBDV
  • Immunosuppression
  • MHC-independent manner
  • Suppressor T cell
  • Suppressor factor

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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