@inproceedings{8fe043c3cc8a44558f18bb41cb180060,
title = "Hyperbolic space sparse coding with its application on prediction of Alzheimer{\textquoteright}s disease in mild cognitive impairment",
abstract = "Mild Cognitive Impairment (MCI) is a transitional stage between normal age-related cognitive decline and Alzheimer{\textquoteright}s disease (AD). Here we introduce a hyperbolic space sparse coding method to predict impending decline of MCI patients to dementia using surface measures of ventricular enlargement. First,we compute diffeomorphic mappings between ventricular surfaces using a canonical hyperbolic parameter space with consistent boundary conditions and surface tensorbased morphometry is computed to measure local surface deformations. Second,ring-shaped patches of TBM features are selected according to the geometric structure of the hyperbolic parameter space to initialize a dictionary. Sparse coding is then applied on the patch features to learn sparse codes and update the dictionary. Finally,we adopt max-pooling to reduce the feature dimensions and apply Adaboost to predict AD in MCI patients (N = 133) from the Alzheimer{\textquoteright}s Disease Neuroimaging Initiative baseline dataset. Our work achieved an accuracy rate of 96.7% and outperformed some other morphometry measures. The hyperbolic space sparse coding method may offer a more sensitive tool to study AD and its early symptom.",
keywords = "Hyperbolic parameter space, Mild Cognitive Impairment, Ring-shaped patches, Sparse coding and dictionary learning",
author = "Jie Zhang and Jie Shi and Cynthia Stonnington and Qingyang Li and Gutman, {Boris A.} and Kewei Chen and Reiman, {Eric M.} and Richard Caselli and Thompson, {Paul M.} and Jieping Ye and Yalin Wang",
note = "Funding Information: The research was supported in part by NIH (R21AG043760, R21AG049216, RF1AG051710, R01AG031581, P30AG19610 and U54EB020403) and NSF (DMS-1413417 and IIS-1421165). Publisher Copyright: {\textcopyright} Springer International Publishing AG 2016.; 1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 ; Conference date: 21-10-2016 Through 21-10-2016",
year = "2016",
doi = "10.1007/978-3-319-46720-7_38",
language = "English (US)",
isbn = "9783319467191",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "326--334",
editor = "Sebastian Ourselin and Leo Joskowicz and Sabuncu, {Mert R.} and William Wells and Gozde Unal",
booktitle = "Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings",
}