Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

Ikuo Nakanishi, Chiho Nishizawa, Kei Ohkubo, Keizo Takeshita, Kazuo T. Suzuki, Toshihiko Ozawa, Sidney M. Hecht, Masayuki Tanno, Shoko Sueyoshi, Naoki Miyata, Haruhiro Okuda, Shunichi Fukuzumi, Nobuo Ikota, Kiyoshi Fukuhara

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, and catechol.

Original languageEnglish (US)
Pages (from-to)3263-3265
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number18
DOIs
StatePublished - Sep 21 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Nakanishi, I., Nishizawa, C., Ohkubo, K., Takeshita, K., Suzuki, K. T., Ozawa, T., Hecht, S. M., Tanno, M., Sueyoshi, S., Miyata, N., Okuda, H., Fukuzumi, S., Ikota, N., & Fukuhara, K. (2005). Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue. Organic and Biomolecular Chemistry, 3(18), 3263-3265. https://doi.org/10.1039/b509447j