Hydrodynamic tweezers: Single -cell trapping arrays for cell dynamics

Barry R. Lutz, Deirdre R. Meldrum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Hydrodynamic tweezers provide strong, adjustable fluid forces that trap single cells without surface contact or cell modification. We show that trapping arrays can be created under continuous net flow needed for delivery of nutrients and reagents in dynamic measurements. We quantify the competition between net flow and trapping, and we find that traps withstand net flow velocities up to 1 cm/sec. Traps can be arbitrarily numbered-up to create arrays that capture cells from a flowing fluid stream. This trapping approach provides a promising tool for parallel dynamic measurement of many individual cells in a controlled chemical environment.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages512-514
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

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Keywords

  • Cell trapping
  • Microfluidics
  • Steady streaming

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Lutz, B. R., & Meldrum, D. R. (2005). Hydrodynamic tweezers: Single -cell trapping arrays for cell dynamics. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 512-514). (Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences; Vol. 1). Transducer Research Foundation.