Hybrid Nanostructures from the Self-Assembly of Proteins and DNA

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Nanotechnology as a field seeks to create structures and materials that can manipulate and influence the microscopic world in much the same way that traditional machines and devices work on the macroscopic world. For inspiration, scientists have turned to biology, which has countless examples of nanoscale structures and machines that can carry out complex functions. Biological molecules such as proteins and DNA are particularly attractive for this purpose because of their programmable nature and functional relevance. In this review, we discuss hybrid nanostructures that integrate the structural programmability of DNA nanotechnology with the chemical and functional diversity of proteins. We discuss strategies for creating complex, integrated structures with these two biomolecules, as well as four areas where they have found application. In the long term, the field of “protein-DNA nanotechnology” has the potential to create materials with capabilities that rival, or even surpass, nature.

Original languageEnglish (US)
StateAccepted/In press - 2020


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ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Biochemistry, medical
  • Materials Chemistry


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