Human papillomavirus prevalence among American indian women of the Great Plains

Naomi R. Lee, Rachel L. Winer, Stephen Cherne, Carolyn J. Noonan, Lonnie Nelson, Angela Gonzales, Jason G. Umans, Dedra Buchwald

Research output: Contribution to journalArticle

Abstract

Background High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence. Methods Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes. Results The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. hrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years. Conclusions HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.

Original languageEnglish (US)
Pages (from-to)908-915
Number of pages8
JournalJournal of Infectious Diseases
Volume219
Issue number6
DOIs
StatePublished - Feb 23 2019

Fingerprint

North American Indians
Human papillomavirus 16
Genotype
Uterine Cervical Neoplasms
Human papillomavirus 18
Early Detection of Cancer
Ethnic Groups
Population

Keywords

  • American Indians
  • genotype distribution
  • human papillomavirus (HPV)
  • human papillomavirus vaccination
  • self-sampling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Lee, N. R., Winer, R. L., Cherne, S., Noonan, C. J., Nelson, L., Gonzales, A., ... Buchwald, D. (2019). Human papillomavirus prevalence among American indian women of the Great Plains. Journal of Infectious Diseases, 219(6), 908-915. https://doi.org/10.1093/infdis/jiy600

Human papillomavirus prevalence among American indian women of the Great Plains. / Lee, Naomi R.; Winer, Rachel L.; Cherne, Stephen; Noonan, Carolyn J.; Nelson, Lonnie; Gonzales, Angela; Umans, Jason G.; Buchwald, Dedra.

In: Journal of Infectious Diseases, Vol. 219, No. 6, 23.02.2019, p. 908-915.

Research output: Contribution to journalArticle

Lee, NR, Winer, RL, Cherne, S, Noonan, CJ, Nelson, L, Gonzales, A, Umans, JG & Buchwald, D 2019, 'Human papillomavirus prevalence among American indian women of the Great Plains', Journal of Infectious Diseases, vol. 219, no. 6, pp. 908-915. https://doi.org/10.1093/infdis/jiy600
Lee, Naomi R. ; Winer, Rachel L. ; Cherne, Stephen ; Noonan, Carolyn J. ; Nelson, Lonnie ; Gonzales, Angela ; Umans, Jason G. ; Buchwald, Dedra. / Human papillomavirus prevalence among American indian women of the Great Plains. In: Journal of Infectious Diseases. 2019 ; Vol. 219, No. 6. pp. 908-915.
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abstract = "Background High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40{\%} of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence. Methods Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes. Results The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8{\%}. HPV-51 (7.6{\%}), HPV-58 (5.3{\%}), HPV-52 (4.3{\%}), HPV-18 (4.3{\%}), and HPV-16 (3.9{\%}) were most prevalent. hrHPV prevalence declined with age, from 42.2{\%} in women aged 21-24 years to 27.9{\%} in women aged 50-65 years. Conclusions HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.",
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