Human papillomavirus prevalence among American indian women of the Great Plains

Naomi R. Lee, Rachel L. Winer, Stephen Cherne, Carolyn J. Noonan, Lonnie Nelson, Angela Gonzales, Jason G. Umans, Dedra Buchwald

    Research output: Contribution to journalArticle

    Abstract

    Background High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence. Methods Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes. Results The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. hrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years. Conclusions HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.

    Original languageEnglish (US)
    Pages (from-to)908-915
    Number of pages8
    JournalJournal of Infectious Diseases
    Volume219
    Issue number6
    DOIs
    StatePublished - Feb 23 2019

    Fingerprint

    North American Indians
    Human papillomavirus 16
    Genotype
    Uterine Cervical Neoplasms
    Human papillomavirus 18
    Early Detection of Cancer
    Ethnic Groups
    Population

    Keywords

    • American Indians
    • genotype distribution
    • human papillomavirus (HPV)
    • human papillomavirus vaccination
    • self-sampling

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Infectious Diseases

    Cite this

    Lee, N. R., Winer, R. L., Cherne, S., Noonan, C. J., Nelson, L., Gonzales, A., ... Buchwald, D. (2019). Human papillomavirus prevalence among American indian women of the Great Plains. Journal of Infectious Diseases, 219(6), 908-915. https://doi.org/10.1093/infdis/jiy600

    Human papillomavirus prevalence among American indian women of the Great Plains. / Lee, Naomi R.; Winer, Rachel L.; Cherne, Stephen; Noonan, Carolyn J.; Nelson, Lonnie; Gonzales, Angela; Umans, Jason G.; Buchwald, Dedra.

    In: Journal of Infectious Diseases, Vol. 219, No. 6, 23.02.2019, p. 908-915.

    Research output: Contribution to journalArticle

    Lee, NR, Winer, RL, Cherne, S, Noonan, CJ, Nelson, L, Gonzales, A, Umans, JG & Buchwald, D 2019, 'Human papillomavirus prevalence among American indian women of the Great Plains' Journal of Infectious Diseases, vol. 219, no. 6, pp. 908-915. https://doi.org/10.1093/infdis/jiy600
    Lee, Naomi R. ; Winer, Rachel L. ; Cherne, Stephen ; Noonan, Carolyn J. ; Nelson, Lonnie ; Gonzales, Angela ; Umans, Jason G. ; Buchwald, Dedra. / Human papillomavirus prevalence among American indian women of the Great Plains. In: Journal of Infectious Diseases. 2019 ; Vol. 219, No. 6. pp. 908-915.
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    abstract = "Background High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40{\%} of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence. Methods Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes. Results The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8{\%}. HPV-51 (7.6{\%}), HPV-58 (5.3{\%}), HPV-52 (4.3{\%}), HPV-18 (4.3{\%}), and HPV-16 (3.9{\%}) were most prevalent. hrHPV prevalence declined with age, from 42.2{\%} in women aged 21-24 years to 27.9{\%} in women aged 50-65 years. Conclusions HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.",
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    AU - Umans, Jason G.

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    N2 - Background High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence. Methods Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes. Results The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. hrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years. Conclusions HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.

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