Human neocortical electrical activity recorded on nonpenetrating microwire arrays

Applicability for neuroprostheses

Spencer S. Kellis, Paul A. House, Kyle E. Thomson, Richard Brown, Bradley Greger

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Object: The goal of this study was to determine whether a nonpenetrating, high-density microwire array could provide sufficient information to serve as the interface for decoding motor cortical signals. Methods: Arrays of nonpenetrating microwires were implanted over the human motor cortex in 2 patients. The patients performed directed stereotypical reaching movements in 2 directions. The resulting data were used to determine whether the reach direction could be distinguished through a frequency power analysis. Results: Correlation analysis revealed decreasing signal correlation with distance. The gamma-band power during motor planning allowed binary classification of gross directionality in the reaching movements. The degree of power change was correlated to the underlying gyral pattern. Conclusions: The nonpenetrating microwire platform showed good potential for allowing differentiated signals to be recorded with high spatial fidelity without cortical penetration.

Original languageEnglish (US)
JournalNeurosurgical Focus
Volume27
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

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Motor Cortex
Direction compound

Keywords

  • Electrocorticoencephalography
  • Human
  • Motor cortex
  • Neuroprosthesis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Human neocortical electrical activity recorded on nonpenetrating microwire arrays : Applicability for neuroprostheses. / Kellis, Spencer S.; House, Paul A.; Thomson, Kyle E.; Brown, Richard; Greger, Bradley.

In: Neurosurgical Focus, Vol. 27, No. 1, 2009.

Research output: Contribution to journalArticle

Kellis, Spencer S. ; House, Paul A. ; Thomson, Kyle E. ; Brown, Richard ; Greger, Bradley. / Human neocortical electrical activity recorded on nonpenetrating microwire arrays : Applicability for neuroprostheses. In: Neurosurgical Focus. 2009 ; Vol. 27, No. 1.
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