Human cytomegalovirus intrahost evolution - A new avenue for understanding and controlling herpesvirus infections

Nicholas Renzette, Laura Gibson, Jeffrey D. Jensen, Timothy F. Kowalik

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCurrent opinion in virology
Volume8
DOIs
StatePublished - Oct 2014

ASJC Scopus subject areas

  • Virology

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