Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-β

Eric Bartee, Grant McFadden

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNβ. Here, we demonstrate that this synergistic state is both antiviral and cytostatic for primary human cells. Significantly, we observed that a wide spectrum of transformed human cancer cells have universally lost the ability to induce the TNF/IFNβ synergistic state, as defined by three separate criteria. We hypothesize that the ability to induce the TNF/IFNβ synergistic state is a unique feature of primary cells and is incompatible with cellular immortalization and/or transformation.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalCytokine
Volume47
Issue number3
DOIs
StatePublished - Sep 2009

Keywords

  • Cancer
  • Cytostasis
  • IFN
  • Synergy
  • TNF

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-β'. Together they form a unique fingerprint.

  • Cite this