Human agression and enumerative measures of immunity

Douglas A. Granger, Alan Booth, David R. Johnson

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Objective: A pattern of clinical, behavioral, and experimental findings suggests that individual differences in aggressive behavior may be related to immunologic processes. We evaluated two conflicting models of the relationship: 1) A positive association stems from an adaptive mechanism protecting aggressive individuals from increased exposure to immune stimuli and 2) a negative association is due to potential immunosuppressive effects of high testosterone levels. Methods: We investigated the models using enumerative measures of cellular and humoral immunity in a sample of 4415 men aged 30 to 48 years who were interviewed and underwent a medical examination. Results: Analysis revealed positive (and curvilinear) associations between aggressive behavior and enumerative measures of helper/inducer and suppressor/cytolytic T lymphocytes and B lymphocytes. The aggression-immunity relationship was independent of testosterone level, age, current health status, and negative health behaviors and was most pronounced for helper/inducer T cells. There was no evidence of a negative association between testosterone and any immune measure. Conclusions: In a large sample of men, individual differences in aggressive behavior were positively associated with enumerative measures of cellular immunity.

Original languageEnglish (US)
Pages (from-to)583-590
Number of pages8
JournalPsychosomatic Medicine
Volume62
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Aggression
  • Cellular immunity
  • Health behavior
  • Health status
  • Testosterone

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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