TY - JOUR
T1 - How ticks keep ticking in the adversity of host immune reactions
AU - Jennings, Rachel
AU - Kuang, Yang
AU - Thieme, Horst
AU - Wu, Jianhong
AU - Wu, Xiaotian
N1 - Funding Information:
Acknowledgements This project was initiated during the workshop on “Mathematics inspired by immu-noepidemiology” held at the American Institute of Mathematics (August 24-28, 2015), and the authors and all rodents and deer plagued by ticks gratefully acknowledge the AIM’s support. This research was also financially supported by the National Natural Science Foundation of China (No.11501358, held by XW), the Natural Sciences and Engineering Research Council of Canada and the Canada Research Chairs program (JW), and by NSF grant DMS-1615879 (YK). The authors thank an anonymous referee for helpful comments.
Funding Information:
This project was initiated during the workshop on “Mathematics inspired by immunoepidemiology” held at the American Institute of Mathematics (August 24-28, 2015), and the authors and all rodents and deer plagued by ticks gratefully acknowledge the AIM’s support. This research was also financially supported by the National Natural Science Foundation of China (No.11501358, held by XW), the Natural Sciences and Engineering Research Council of Canada and the Canada Research Chairs program (JW), and by NSF grant DMS-1615879 (YK). The authors thank an anonymous referee for helpful comments.
Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Ixodid ticks are acknowledged as one of the most important hematophagous arthropods because of their ability in transmitting a variety of tick-borne diseases. Mathematical models have been developed, based on emerging knowledge about tick ecology, pathogen epidemiology and their interface, to understand tick population dynamics and tick-borne diseases spread patterns. However, no serious effort has been made to model and assess the impact of host immunity triggered by tick feeding on the distribution of the tick population according to tick stages and on tick population extinction and persistence. Here, we construct a novel mathematical model taking into account the effect of host immunity status on tick population dynamics, and analyze the long-term behaviours of the model solutions. Two threshold values, R 11 and R 22 , are introduced to measure the reproduction ratios for the tick-host interaction in the absence and presence of host immunity. We then show that these two thresholds (sometimes under additional conditions) can be used to predict whether the tick population goes extinct (R 11 < 1) and the tick population grows without bound (R 22 > 1). We also prove tick permanence (persistence and boundedness of the tick population) and the existence of a tick persistence equilibrium if R 22 < 1 < R 11 . As the host species adjust their immunity to tick infestation levels, they form for the tick population an environment with a carrying capacity very much like that in logistic growth. Numerical results show that the host immune reactions decrease the size of the tick population at equilibrium and apparently reduce the tick-borne infection risk.
AB - Ixodid ticks are acknowledged as one of the most important hematophagous arthropods because of their ability in transmitting a variety of tick-borne diseases. Mathematical models have been developed, based on emerging knowledge about tick ecology, pathogen epidemiology and their interface, to understand tick population dynamics and tick-borne diseases spread patterns. However, no serious effort has been made to model and assess the impact of host immunity triggered by tick feeding on the distribution of the tick population according to tick stages and on tick population extinction and persistence. Here, we construct a novel mathematical model taking into account the effect of host immunity status on tick population dynamics, and analyze the long-term behaviours of the model solutions. Two threshold values, R 11 and R 22 , are introduced to measure the reproduction ratios for the tick-host interaction in the absence and presence of host immunity. We then show that these two thresholds (sometimes under additional conditions) can be used to predict whether the tick population goes extinct (R 11 < 1) and the tick population grows without bound (R 22 > 1). We also prove tick permanence (persistence and boundedness of the tick population) and the existence of a tick persistence equilibrium if R 22 < 1 < R 11 . As the host species adjust their immunity to tick infestation levels, they form for the tick population an environment with a carrying capacity very much like that in logistic growth. Numerical results show that the host immune reactions decrease the size of the tick population at equilibrium and apparently reduce the tick-borne infection risk.
KW - Basic reproduction ratios
KW - Extinction
KW - Global stability
KW - Host resistance
KW - Persistence
KW - Quasi-steady-state approximation
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UR - http://www.scopus.com/inward/citedby.url?scp=85057214537&partnerID=8YFLogxK
U2 - 10.1007/s00285-018-1311-1
DO - 10.1007/s00285-018-1311-1
M3 - Article
C2 - 30478760
AN - SCOPUS:85057214537
SN - 0303-6812
VL - 78
SP - 1331
EP - 1364
JO - Journal Of Mathematical Biology
JF - Journal Of Mathematical Biology
IS - 5
ER -