Holistic Atlases of Functional Networks and Interactions Reveal Reciprocal Organizational Architecture of Cortical Function

Jinglei Lv, Xi Jiang, Xiang Li, Dajiang Zhu, Shu Zhang, Shijie Zhao, Hanbo Chen, Tuo Zhang, Xintao Hu, Junwei Han, Jieping Ye, Lei Guo, Tianming Liu

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

For decades, it has been largely unknown to what extent multiple functional networks spatially overlap/interact with each other and jointly realize the total cortical function. Here, by developing novel sparse representation of whole-brain fMRI signals and by using the recently publicly released large-scale Human Connectome Project high-quality fMRI data, we show that a number of reproducible and robust functional networks, including both task-evoked and resting state networks, are simultaneously distributed in distant neuroanatomic areas and substantially spatially overlapping with each other, thus forming an initial collection of holistic atlases of functional networks and interactions (HAFNIs). More interestingly, the HAFNIs revealed two distinct patterns of highly overlapped regions and highly specialized regions and exhibited that these two patterns of areas are reciprocally localized, revealing a novel organizational principle of cortical function.

Original languageEnglish (US)
Article number6960842
Pages (from-to)1120-1131
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Volume62
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Cortical architecture,
  • brain networks
  • fMRI
  • interaction

ASJC Scopus subject areas

  • Biomedical Engineering

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    Lv, J., Jiang, X., Li, X., Zhu, D., Zhang, S., Zhao, S., Chen, H., Zhang, T., Hu, X., Han, J., Ye, J., Guo, L., & Liu, T. (2015). Holistic Atlases of Functional Networks and Interactions Reveal Reciprocal Organizational Architecture of Cortical Function. IEEE Transactions on Biomedical Engineering, 62(4), 1120-1131. [6960842]. https://doi.org/10.1109/TBME.2014.2369495