HLA-sharing, recurrent spontaneous abortion, and the genetic hypothesis

P. W. Hedrick

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A number of studies indicates that there is a high sharing of HLA antigens in couples having recurrent spontaneous abortions. The genetic hypothesis to explain this phenomenon suggests that this fetal loss results from homozygosity of recessive lethal or deleterious alleles in gametic disequilibrium with HLA antigens. Theory predicting the lethality rate is derived when antigens are shared at one, two or three loci, given that the disequilibrium is absolute. In addition, the effects of partial disequilibrium, inbreeding, and segregation distortion on the lethal proportion are examined.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalGenetics
Volume119
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Genetics

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