HLA and mate selection: No evidence in South Amerindians

Philip W. Hedrick, Francis L. Black

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

There have been reports of nonrandom mating (negative-assortative mating) or preference for individuals of different major histocompatibility complex (MHC) genotypes in both mice and humans. We have examined the association of HLA-A and HLA-B genotypes, both for each locus by itself and for two-locus genotypes, in mates of 194 couples from 11 South Amerindian tribes. The proportion of couples sampled averaged >50% of the total matings with progeny for 10 of the tribes. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalAmerican Journal of Human Genetics
Volume61
Issue number3
StatePublished - Sep 1997

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Marriage
Genotype
Major Histocompatibility Complex
HLA-A Antigens
HLA-B Antigens

ASJC Scopus subject areas

  • Genetics

Cite this

HLA and mate selection : No evidence in South Amerindians. / Hedrick, Philip W.; Black, Francis L.

In: American Journal of Human Genetics, Vol. 61, No. 3, 09.1997, p. 505-511.

Research output: Contribution to journalArticle

Hedrick, PW & Black, FL 1997, 'HLA and mate selection: No evidence in South Amerindians', American Journal of Human Genetics, vol. 61, no. 3, pp. 505-511.
Hedrick, Philip W. ; Black, Francis L. / HLA and mate selection : No evidence in South Amerindians. In: American Journal of Human Genetics. 1997 ; Vol. 61, No. 3. pp. 505-511.
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