Abstract
There have been reports of nonrandom mating (negative-assortative mating) or preference for individuals of different major histocompatibility complex (MHC) genotypes in both mice and humans. We have examined the association of HLA-A and HLA-B genotypes, both for each locus by itself and for two-locus genotypes, in mates of 194 couples from 11 South Amerindian tribes. The proportion of couples sampled averaged >50% of the total matings with progeny for 10 of the tribes. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians.
Original language | English (US) |
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Pages (from-to) | 505-511 |
Number of pages | 7 |
Journal | American Journal of Human Genetics |
Volume | 61 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1997 |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)