High-throughput screening for efficient microbial biotechnology

Aditya Sarnaik, Arren Liu, David Nielsen, Arul M. Varman

Research output: Contribution to journalReview article

Abstract

Microbial systems have been widely studied and exploited through genetic engineering to address industrial needs and societal challenges. However, owing to their complexity, singular approaches often do not yield desired or optimal results, pushing researchers to explore combinatorial strategies. With advances in synthetic biology, various methods can readily be employed to generate large and comprehensive libraries. To serve as tractable tools, however, this capability necessitates the development of high-throughput screening (HTS) techniques to identify the best performing strain and/or those carrying the desired trait. Owing to their miniaturization, time efficiency, potential for automation, and so on, HTS enables comprehensive exploration of diverse experimental landscapes. Herein, we review the recent and novel HTS approaches and applications in the realm of microbial biotechnology.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalCurrent Opinion in Biotechnology
Volume64
DOIs
StatePublished - Aug 2020

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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