High-throughput multi-residue quantification of contaminants of emerging concern in wastewaters enabled using direct injection liquid chromatography-tandem mass spectrometry

Keng Tiong Ng, Helena Rapp-Wright, Melanie Egli, Alicia Hartmann, Joshua C. Steele, Juan Eduardo Sosa-Hernández, Elda M. Melchor-Martínez, Matthew Jacobs, Blánaid White, Fiona Regan, Roberto Parra-Saldivar, Lewis Couchman, Rolf U. Halden, Leon P. Barron

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A rapid quantitative method for 135 contaminants of emerging concern (CECs) in untreated wastewater enabled with direct injection liquid chromatography-tandem mass spectrometry is presented. All compounds were analysed within 5 min on a short biphenyl cartridge using only 10 μL of filtered sample per injection. Up to 76 compounds were monitored simultaneously during the gradient (including mostly two transitions per compound and stable isotope-labelled analogues) while yielding >10 data points per peak. Evaluation of seven solid phase extraction sorbents showed no advantage for wastewater matrix removal. Excellent linearity, range, accuracy and precision was achieved for most compounds. Matrix effects were <11 % and detection limits were <30 ng L−1 on average. Application to untreated wastewater samples from three wastewater treatment works in the UK, USA and Mexico, enabled quantification of 56 compounds. Banned and EU ‘watch-list’ substances are critically discussed, including pesticides, macrolide antibiotics, diclofenac, illicit drugs as well as multiple pharmaceuticals and biocides. This high-throughput method sets a new standard for the speedy and confident determination of over a hundred CECs in wastewater at the part-per-trillion level, as demonstrated by performing over 260 injections per day.

Original languageEnglish (US)
Article number122933
JournalJournal of Hazardous Materials
Volume398
DOIs
StatePublished - Nov 5 2020

Keywords

  • Direct injection LC–MS/MS
  • Illicit drugs
  • Pesticides
  • Pharmaceuticals
  • Wastewater

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

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