@inproceedings{46443daf263a4a06ac06ebf54622425e,
title = "High throughput formation and measurement of occlusive thrombosis in porcine blood",
abstract = "Understanding and treating cardiovascular disease can benefit greatly from the development of low volume, high throughput tools to study thrombosis. We have designed, fabricated, and validated a microfluidic device to induce shear rates from 4300-7100 s-1 using only 10 mL of whole blood for 4 simultaneous assays to measure occlusive thrombosis optically. Shear rates were confirmed by flow rate and particle imaging velocimetry. Thrombosis measurements showed similar acute growth rates for all shear rates while time to acute growth onset and occlusion depend on initial shear rate. Applications range from unravelling the blood clotting cascade to drug dosage response measurement.",
keywords = "Blood, Microfluidics, Platelets, Shear, Thrombosis",
author = "Melissa Li and Angela Sodemann and Jeremy Ackerman and Rhett Mayor and Craig Forest",
year = "2009",
month = jan,
day = "1",
language = "English (US)",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "445--447",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}