High resolution mass spectrometry. Bufadienolides I

Peter Brown, Yoshiaki Kamano, George Pettit

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Complete low resolution mass spectra and some high resolution data are presented and discussed for a series of naturally occurring 14β‐hydroxy bufadienolides (toad venoms) and their derivatives, but excluding compounds with a 14β,15β‐epoxy group. The bufadienolides employed were bufalin, bufotalin, gamabufotalin, telocinobufagin, arenobufagin, 3β‐acetoxybufotalien, 3β‐acetoxyhellebrigenin, 3β‐acetoxybufalin, 3‐ketobufalin, 14‐anhydrobufalin, 3β‐acetoxy‐15‐ketobufalin and 15α‐hydroxybufalin. The relatively unsaturated 2‐pyrone functionality at C‐17β has been used as an integral label to distinguish (from elemental composition data) ions containing it, from those coming from other parts of the molecule that do not. Structural ‘ion types’ are proposed to interpret this spectral data, and the prognosis for structure elucidation of other bufadienolides by high resolution mass spectrometry appears good.

Original languageEnglish (US)
Pages (from-to)47-74
Number of pages28
JournalOrganic Mass Spectrometry
Volume6
Issue number1
DOIs
StatePublished - 1972

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Bufanolides
Mass spectrometry
Mass Spectrometry
mass spectroscopy
prognosis
Amphibian Venoms
high resolution
Ions
mass spectra
Labels
ions
Derivatives
Molecules
Chemical analysis
molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Instrumentation

Cite this

High resolution mass spectrometry. Bufadienolides I. / Brown, Peter; Kamano, Yoshiaki; Pettit, George.

In: Organic Mass Spectrometry, Vol. 6, No. 1, 1972, p. 47-74.

Research output: Contribution to journalArticle

Brown, Peter ; Kamano, Yoshiaki ; Pettit, George. / High resolution mass spectrometry. Bufadienolides I. In: Organic Mass Spectrometry. 1972 ; Vol. 6, No. 1. pp. 47-74.
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