Abstract
Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO<inf>2peak</inf>), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO<inf>2peak</inf> determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO<inf>2peak</inf> (pre = 19.2 ± 5.2 ml.kg<sup>-1</sup>.min<sup>-1</sup>; post = 21.0 ± 5.2 ml.kg<sup>-1</sup>.min<sup>-1</sup>; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m<sup>2</sup>; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO<inf>2peak</inf> and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 753-758 |
| Number of pages | 6 |
| Journal | Journal of Applied Physiology |
| Volume | 119 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 15 2015 |
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Keywords
- Diastolic dysfunction
- Exercise training
- Heart failure with preserved ejection fraction
- High-intensity interval exercise
- Peak oxygen uptake
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction : A pilot study. / Angadi, Siddhartha; Mookadam, Farouk; Lee, Chong; Tucker, Wesley J.; Haykowsky, Mark J.; Gaesser, Glenn.
In: Journal of Applied Physiology, Vol. 119, No. 6, 15.09.2015, p. 753-758.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction
T2 - A pilot study
AU - Angadi, Siddhartha
AU - Mookadam, Farouk
AU - Lee, Chong
AU - Tucker, Wesley J.
AU - Haykowsky, Mark J.
AU - Gaesser, Glenn
PY - 2015/9/15
Y1 - 2015/9/15
N2 - Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO2peak), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO2peak determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO2peak (pre = 19.2 ± 5.2 ml.kg-1.min-1; post = 21.0 ± 5.2 ml.kg-1.min-1; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m2; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO2peak and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.
AB - Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO2peak), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO2peak determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO2peak (pre = 19.2 ± 5.2 ml.kg-1.min-1; post = 21.0 ± 5.2 ml.kg-1.min-1; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m2; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO2peak and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.
KW - Diastolic dysfunction
KW - Exercise training
KW - Heart failure with preserved ejection fraction
KW - High-intensity interval exercise
KW - Peak oxygen uptake
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U2 - 10.1152/japplphysiol.00518.2014
DO - 10.1152/japplphysiol.00518.2014
M3 - Article
VL - 119
SP - 753
EP - 758
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -