High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction

A pilot study

Siddhartha Angadi, Farouk Mookadam, Chong Lee, Wesley J. Tucker, Mark J. Haykowsky, Glenn Gaesser

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO<inf>2peak</inf>), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO<inf>2peak</inf> determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO<inf>2peak</inf> (pre = 19.2 ± 5.2 ml.kg<sup>-1</sup>.min<sup>-1</sup>; post = 21.0 ± 5.2 ml.kg<sup>-1</sup>.min<sup>-1</sup>; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m<sup>2</sup>; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO<inf>2peak</inf> and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.

Original languageEnglish (US)
Pages (from-to)753-758
Number of pages6
JournalJournal of Applied Physiology
Volume119
Issue number6
DOIs
StatePublished - Sep 15 2015

Fingerprint

Heart Failure
Exercise
Left Ventricular Dysfunction
Dilatation
Heart Rate
Brachial Artery
High-Intensity Interval Training
Exercise Test
Echocardiography
Oxygen
Morbidity
Mortality

Keywords

  • Diastolic dysfunction
  • Exercise training
  • Heart failure with preserved ejection fraction
  • High-intensity interval exercise
  • Peak oxygen uptake

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction : A pilot study. / Angadi, Siddhartha; Mookadam, Farouk; Lee, Chong; Tucker, Wesley J.; Haykowsky, Mark J.; Gaesser, Glenn.

In: Journal of Applied Physiology, Vol. 119, No. 6, 15.09.2015, p. 753-758.

Research output: Contribution to journalArticle

@article{cb028385afdc4a2a9f6989b84b9c2262,
title = "High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: A pilot study",
abstract = "Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO2peak), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90{\%} peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70{\%} peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO2peak determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO2peak (pre = 19.2 ± 5.2 ml.kg-1.min-1; post = 21.0 ± 5.2 ml.kg-1.min-1; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7{\%}; post = 7.0 ± 4.2{\%}). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m2; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO2peak and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.",
keywords = "Diastolic dysfunction, Exercise training, Heart failure with preserved ejection fraction, High-intensity interval exercise, Peak oxygen uptake",
author = "Siddhartha Angadi and Farouk Mookadam and Chong Lee and Tucker, {Wesley J.} and Haykowsky, {Mark J.} and Glenn Gaesser",
year = "2015",
month = "9",
day = "15",
doi = "10.1152/japplphysiol.00518.2014",
language = "English (US)",
volume = "119",
pages = "753--758",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction

T2 - A pilot study

AU - Angadi, Siddhartha

AU - Mookadam, Farouk

AU - Lee, Chong

AU - Tucker, Wesley J.

AU - Haykowsky, Mark J.

AU - Gaesser, Glenn

PY - 2015/9/15

Y1 - 2015/9/15

N2 - Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO2peak), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO2peak determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO2peak (pre = 19.2 ± 5.2 ml.kg-1.min-1; post = 21.0 ± 5.2 ml.kg-1.min-1; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m2; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO2peak and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.

AB - Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Exercise training is an established adjuvant therapy in heart failure; however, the effects of high-intensity interval training (HIIT) in HFpEF are unknown. We compared the effects of HIIT vs. moderate-intensity aerobic continuous training (MI-ACT) on peak oxygen uptake (VO2peak), left ventricular diastolic dysfunction, and endothelial function in patients with HFpEF. Nineteen patients with HFpEF (age 70 ± 8.3 yr) were randomized to either HIIT (4 × 4 min at 85-90% peak heart rate, with 3 min active recovery) or MI-ACT (30 min at 70% peak heart rate). Fifteen patients completed exercise training (HIIT: n = 9; MI-ACT: n = 6). Patients trained 3 days/wk for 4 wk. Before and after training patients underwent a treadmill test for VO2peak determination, 2D-echocardiography for assessment of left ventricular diastolic dysfunction, and brachial artery flow-mediated dilation (FMD) for assessment of endothelial function. HIIT improved VO2peak (pre = 19.2 ± 5.2 ml.kg-1.min-1; post = 21.0 ± 5.2 ml.kg-1.min-1; P = 0.04) and left ventricular diastolic dysfunction grade (pre = 2.1 ± 0.3; post = 1.3 ± 0.7; P = 0.02), but FMD was unchanged (pre = 6.9 ± 3.7%; post = 7.0 ± 4.2%). No changes were observed following MI-ACT. A trend for reduced left atrial volume index was observed following HIIT compared with MI-ACT (-3.3 ± 6.6 vs. +5.8 ± 10.7 ml/m2; P = 0.06). In HFpEF patients 4 wk of HIIT significantly improved VO2peak and left ventricular diastolic dysfunction. HIIT may provide a more robust stimulus than MI-ACT for early exercise training adaptations in HFpEF.

KW - Diastolic dysfunction

KW - Exercise training

KW - Heart failure with preserved ejection fraction

KW - High-intensity interval exercise

KW - Peak oxygen uptake

UR - http://www.scopus.com/inward/record.url?scp=84942244941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942244941&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00518.2014

DO - 10.1152/japplphysiol.00518.2014

M3 - Article

VL - 119

SP - 753

EP - 758

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -