HIGH-EFFICIENCY HEMOFILTRATION.

William J. Dorson, Vincent Pizziconi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

High-efficiency hemofiltration (HF) was accomplished with an axial-spiral wound membrane device using recirculation of the blood and the cleansed filtrate. The blood side mesh design, thickness, and orientation determined the amount of recirculation needed to achieve high efficiency. The total protein, hematocrit, and pH also affected the degree of efficiency. Solute clearance, particularly of larger molecules, was adversely affected by inefficient hemofiltration conditions. As a result, clinical comparisons of hemodialysis with hemofiltration should be made only with high-efficiency hemofilters. High-efficiency HF can be used as an artificial kidney with either a minimum membrane surface area or a minimum treatment time. The preclinical results showed no clotting problems, and the devices were reusable.

Original languageEnglish (US)
Pages (from-to)756-771
Number of pages16
JournalASAIO Transactions
Volume33
Issue number3
StatePublished - Jul 1987
Externally publishedYes

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Hemofiltration
Artificial Kidneys
Blood
Equipment and Supplies
Membranes
Hematocrit
Renal Dialysis
Wounds and Injuries
Proteins
Molecules
Therapeutics

ASJC Scopus subject areas

  • Biophysics

Cite this

HIGH-EFFICIENCY HEMOFILTRATION. / Dorson, William J.; Pizziconi, Vincent.

In: ASAIO Transactions, Vol. 33, No. 3, 07.1987, p. 756-771.

Research output: Contribution to journalArticle

Dorson, WJ & Pizziconi, V 1987, 'HIGH-EFFICIENCY HEMOFILTRATION.', ASAIO Transactions, vol. 33, no. 3, pp. 756-771.
Dorson, William J. ; Pizziconi, Vincent. / HIGH-EFFICIENCY HEMOFILTRATION. In: ASAIO Transactions. 1987 ; Vol. 33, No. 3. pp. 756-771.
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