HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways

Sun Hee Kim, Dingzhi Wang, Yun Yong Park, Hiroshi Katoh, Ofer Margalit, Michal Sheffer, Hong Wu, Vijaykumar R. Holla, Ju Seog Lee, Raymond N. DuBois

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.

    Original languageEnglish (US)
    Pages (from-to)159-165
    Number of pages7
    JournalCancer Letters
    Volume341
    Issue number2
    DOIs
    StatePublished - Dec 1 2013

    Keywords

    • Colorectal cancer
    • HIF-1α
    • HIG2
    • Hypoxia
    • Normoxia
    • Survival

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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  • Cite this

    Kim, S. H., Wang, D., Park, Y. Y., Katoh, H., Margalit, O., Sheffer, M., Wu, H., Holla, V. R., Lee, J. S., & DuBois, R. N. (2013). HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways. Cancer Letters, 341(2), 159-165. https://doi.org/10.1016/j.canlet.2013.07.028