Abstract
HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-165 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 341 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1 2013 |
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Keywords
- Colorectal cancer
- HIF-1α
- HIG2
- Hypoxia
- Normoxia
- Survival
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways. / Kim, Sun Hee; Wang, Dingzhi; Park, Yun Yong; Katoh, Hiroshi; Margalit, Ofer; Sheffer, Michal; Wu, Hong; Holla, Vijaykumar R.; Lee, Ju Seog; DuBois, Raymond N.
In: Cancer Letters, Vol. 341, No. 2, 01.12.2013, p. 159-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways
AU - Kim, Sun Hee
AU - Wang, Dingzhi
AU - Park, Yun Yong
AU - Katoh, Hiroshi
AU - Margalit, Ofer
AU - Sheffer, Michal
AU - Wu, Hong
AU - Holla, Vijaykumar R.
AU - Lee, Ju Seog
AU - DuBois, Raymond N.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.
AB - HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.
KW - Colorectal cancer
KW - HIF-1α
KW - HIG2
KW - Hypoxia
KW - Normoxia
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84887159148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887159148&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2013.07.028
DO - 10.1016/j.canlet.2013.07.028
M3 - Article
C2 - 23916472
AN - SCOPUS:84887159148
VL - 341
SP - 159
EP - 165
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -