Abstract
Novel single exon genes Aβ4-7 comprising the Aβ6 gene family have been cloned from mouse mutants surviving transplantable metastatic tumors. Their protein coding sequences are similar to H2-Ab cDNA which encodes antigen-binding molecules of antigen presenting cells (APC); their promoters and/or signal sequences are unrelated to Ab sequences but found in other eukaryotic genes. Aβ4b protein was demonstrated on macrophages and B cells that are APC. The Aβ6w302 appears to be an ancient gene ancestral to major histocompatibility complex (MHC) class II β genes. However, unlike the MHC class II, the Aβ4-7 genes are not involved in skin graft rejection. Despite inbreeding, the Aβ6w302 locus remains unfixed in several strains of mice. The number of Aβ genes and their alleles varied between individual mice; they do not map into the H2 region but appear to be scattered over the genome. The Aβ6 gene family is molecularly unstable in Aβ6w302-positive (but not in Aβ6w302-negative) mice which are somatic mosaics for these genes. Biological features of Aβ4-7 genes make them remarkably different from the classical MHC gene system. All available evidence strongly suggests that these genes control susceptibility/resistance to the spread of metastatic tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1091-1110 |
| Number of pages | 20 |
| Journal | Molecular Immunology |
| Volume | 37 |
| Issue number | 18 |
| DOIs | |
| State | Published - Jul 24 2001 |
| Externally published | Yes |
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Keywords
- Cancer metastasis
- Immune escape
- Major histocompatibility complex class II genetics
- Natural selection for heterozygosity
- Somatic mutations
ASJC Scopus subject areas
- Immunology
- Molecular Biology
Cite this
Hidden variables : Unstable Aβ chain genes encoding antigen recognition structures in tumor survivors. / Liu, Yinong; McMinimy, Douglas L.; Savinov, Alexei Y.; Johnson, Kevin A.; Kremlev, Sergey G.; Chapoval, Andrei; Egorov, Igor K.
In: Molecular Immunology, Vol. 37, No. 18, 24.07.2001, p. 1091-1110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hidden variables
T2 - Unstable Aβ chain genes encoding antigen recognition structures in tumor survivors
AU - Liu, Yinong
AU - McMinimy, Douglas L.
AU - Savinov, Alexei Y.
AU - Johnson, Kevin A.
AU - Kremlev, Sergey G.
AU - Chapoval, Andrei
AU - Egorov, Igor K.
PY - 2001/7/24
Y1 - 2001/7/24
N2 - Novel single exon genes Aβ4-7 comprising the Aβ6 gene family have been cloned from mouse mutants surviving transplantable metastatic tumors. Their protein coding sequences are similar to H2-Ab cDNA which encodes antigen-binding molecules of antigen presenting cells (APC); their promoters and/or signal sequences are unrelated to Ab sequences but found in other eukaryotic genes. Aβ4b protein was demonstrated on macrophages and B cells that are APC. The Aβ6w302 appears to be an ancient gene ancestral to major histocompatibility complex (MHC) class II β genes. However, unlike the MHC class II, the Aβ4-7 genes are not involved in skin graft rejection. Despite inbreeding, the Aβ6w302 locus remains unfixed in several strains of mice. The number of Aβ genes and their alleles varied between individual mice; they do not map into the H2 region but appear to be scattered over the genome. The Aβ6 gene family is molecularly unstable in Aβ6w302-positive (but not in Aβ6w302-negative) mice which are somatic mosaics for these genes. Biological features of Aβ4-7 genes make them remarkably different from the classical MHC gene system. All available evidence strongly suggests that these genes control susceptibility/resistance to the spread of metastatic tumors.
AB - Novel single exon genes Aβ4-7 comprising the Aβ6 gene family have been cloned from mouse mutants surviving transplantable metastatic tumors. Their protein coding sequences are similar to H2-Ab cDNA which encodes antigen-binding molecules of antigen presenting cells (APC); their promoters and/or signal sequences are unrelated to Ab sequences but found in other eukaryotic genes. Aβ4b protein was demonstrated on macrophages and B cells that are APC. The Aβ6w302 appears to be an ancient gene ancestral to major histocompatibility complex (MHC) class II β genes. However, unlike the MHC class II, the Aβ4-7 genes are not involved in skin graft rejection. Despite inbreeding, the Aβ6w302 locus remains unfixed in several strains of mice. The number of Aβ genes and their alleles varied between individual mice; they do not map into the H2 region but appear to be scattered over the genome. The Aβ6 gene family is molecularly unstable in Aβ6w302-positive (but not in Aβ6w302-negative) mice which are somatic mosaics for these genes. Biological features of Aβ4-7 genes make them remarkably different from the classical MHC gene system. All available evidence strongly suggests that these genes control susceptibility/resistance to the spread of metastatic tumors.
KW - Cancer metastasis
KW - Immune escape
KW - Major histocompatibility complex class II genetics
KW - Natural selection for heterozygosity
KW - Somatic mutations
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U2 - 10.1016/S0161-5890(01)00029-3
DO - 10.1016/S0161-5890(01)00029-3
M3 - Article
VL - 37
SP - 1091
EP - 1110
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 18
ER -