Heritability and genetic integration of tooth size in the South Carolina Gullah

Christopher Stojanowski, Kathleen S. Paul, Andrew C. Seidel, William N. Duncan, Debbie Guatelli-Steinberg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: This article provides estimates of narrow-sense heritability and genetic pleiotropy for mesiodistal tooth dimensions for a sample of 20th century African American individuals. Results inform biological distance analysis and offer insights into patterns of integration in the human dentition. Materials and Methods: Maximum mesiodistal crown dimensions were measured using Hillson-FitzGerald calipers on 469 stone dental casts from the Menegaz-Bock Collection. Narrow-sense heritability estimates and genetic and phenotypic correlations were estimated using SOLAR 8.1.1 with covariate screening for age, sex, age*sex interaction, and birth year. Results: Heritability estimates were moderate (∼0.10 - 0.90; h2 mean=0.51) for most measured variables with sex as the only significant covariate. Patterns of genetic correlation indicate strong integration across tooth classes, except molars. Comparison of these results to previously published work suggests lower overall heritability relative to other human populations and much stronger genetic integration across tooth classes than obtained from nonhuman primate genetic pleiotropy estimates. Conclusions: These results suggest that the high heritabilities previously published may reflect overestimates inherent in previous study designs; as such the standard estimate of 0.55 used in biodistance analyses may not be appropriate. For the Gullah, isolation and endogamy coupled with elevated levels of physiological and economic stress may suppress narrow-sense heritability estimates. Pleiotropy analyses suggest a more highly integrated dentition in humans than in other mammals.

Original languageEnglish (US)
JournalAmerican Journal of Physical Anthropology
DOIs
StateAccepted/In press - 2017

Fingerprint

Tooth
Genetic Pleiotropy
Dentition
Crowns
African Americans
Primates
Mammals
Economics
Parturition
social isolation
Population
interaction
economics

Keywords

  • Biodistance
  • Heritability
  • Odontometrics
  • Pleiotropy
  • Quantitative genetics

ASJC Scopus subject areas

  • Anatomy
  • Anthropology

Cite this

Heritability and genetic integration of tooth size in the South Carolina Gullah. / Stojanowski, Christopher; Paul, Kathleen S.; Seidel, Andrew C.; Duncan, William N.; Guatelli-Steinberg, Debbie.

In: American Journal of Physical Anthropology, 2017.

Research output: Contribution to journalArticle

Stojanowski, Christopher ; Paul, Kathleen S. ; Seidel, Andrew C. ; Duncan, William N. ; Guatelli-Steinberg, Debbie. / Heritability and genetic integration of tooth size in the South Carolina Gullah. In: American Journal of Physical Anthropology. 2017.
@article{9edf6e00f47a44358fe6d595bac9ae46,
title = "Heritability and genetic integration of tooth size in the South Carolina Gullah",
abstract = "Objectives: This article provides estimates of narrow-sense heritability and genetic pleiotropy for mesiodistal tooth dimensions for a sample of 20th century African American individuals. Results inform biological distance analysis and offer insights into patterns of integration in the human dentition. Materials and Methods: Maximum mesiodistal crown dimensions were measured using Hillson-FitzGerald calipers on 469 stone dental casts from the Menegaz-Bock Collection. Narrow-sense heritability estimates and genetic and phenotypic correlations were estimated using SOLAR 8.1.1 with covariate screening for age, sex, age*sex interaction, and birth year. Results: Heritability estimates were moderate (∼0.10 - 0.90; h2 mean=0.51) for most measured variables with sex as the only significant covariate. Patterns of genetic correlation indicate strong integration across tooth classes, except molars. Comparison of these results to previously published work suggests lower overall heritability relative to other human populations and much stronger genetic integration across tooth classes than obtained from nonhuman primate genetic pleiotropy estimates. Conclusions: These results suggest that the high heritabilities previously published may reflect overestimates inherent in previous study designs; as such the standard estimate of 0.55 used in biodistance analyses may not be appropriate. For the Gullah, isolation and endogamy coupled with elevated levels of physiological and economic stress may suppress narrow-sense heritability estimates. Pleiotropy analyses suggest a more highly integrated dentition in humans than in other mammals.",
keywords = "Biodistance, Heritability, Odontometrics, Pleiotropy, Quantitative genetics",
author = "Christopher Stojanowski and Paul, {Kathleen S.} and Seidel, {Andrew C.} and Duncan, {William N.} and Debbie Guatelli-Steinberg",
year = "2017",
doi = "10.1002/ajpa.23290",
language = "English (US)",
journal = "American Journal of Physical Anthropology",
issn = "0002-9483",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Heritability and genetic integration of tooth size in the South Carolina Gullah

AU - Stojanowski, Christopher

AU - Paul, Kathleen S.

AU - Seidel, Andrew C.

AU - Duncan, William N.

AU - Guatelli-Steinberg, Debbie

PY - 2017

Y1 - 2017

N2 - Objectives: This article provides estimates of narrow-sense heritability and genetic pleiotropy for mesiodistal tooth dimensions for a sample of 20th century African American individuals. Results inform biological distance analysis and offer insights into patterns of integration in the human dentition. Materials and Methods: Maximum mesiodistal crown dimensions were measured using Hillson-FitzGerald calipers on 469 stone dental casts from the Menegaz-Bock Collection. Narrow-sense heritability estimates and genetic and phenotypic correlations were estimated using SOLAR 8.1.1 with covariate screening for age, sex, age*sex interaction, and birth year. Results: Heritability estimates were moderate (∼0.10 - 0.90; h2 mean=0.51) for most measured variables with sex as the only significant covariate. Patterns of genetic correlation indicate strong integration across tooth classes, except molars. Comparison of these results to previously published work suggests lower overall heritability relative to other human populations and much stronger genetic integration across tooth classes than obtained from nonhuman primate genetic pleiotropy estimates. Conclusions: These results suggest that the high heritabilities previously published may reflect overestimates inherent in previous study designs; as such the standard estimate of 0.55 used in biodistance analyses may not be appropriate. For the Gullah, isolation and endogamy coupled with elevated levels of physiological and economic stress may suppress narrow-sense heritability estimates. Pleiotropy analyses suggest a more highly integrated dentition in humans than in other mammals.

AB - Objectives: This article provides estimates of narrow-sense heritability and genetic pleiotropy for mesiodistal tooth dimensions for a sample of 20th century African American individuals. Results inform biological distance analysis and offer insights into patterns of integration in the human dentition. Materials and Methods: Maximum mesiodistal crown dimensions were measured using Hillson-FitzGerald calipers on 469 stone dental casts from the Menegaz-Bock Collection. Narrow-sense heritability estimates and genetic and phenotypic correlations were estimated using SOLAR 8.1.1 with covariate screening for age, sex, age*sex interaction, and birth year. Results: Heritability estimates were moderate (∼0.10 - 0.90; h2 mean=0.51) for most measured variables with sex as the only significant covariate. Patterns of genetic correlation indicate strong integration across tooth classes, except molars. Comparison of these results to previously published work suggests lower overall heritability relative to other human populations and much stronger genetic integration across tooth classes than obtained from nonhuman primate genetic pleiotropy estimates. Conclusions: These results suggest that the high heritabilities previously published may reflect overestimates inherent in previous study designs; as such the standard estimate of 0.55 used in biodistance analyses may not be appropriate. For the Gullah, isolation and endogamy coupled with elevated levels of physiological and economic stress may suppress narrow-sense heritability estimates. Pleiotropy analyses suggest a more highly integrated dentition in humans than in other mammals.

KW - Biodistance

KW - Heritability

KW - Odontometrics

KW - Pleiotropy

KW - Quantitative genetics

UR - http://www.scopus.com/inward/record.url?scp=85027516282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027516282&partnerID=8YFLogxK

U2 - 10.1002/ajpa.23290

DO - 10.1002/ajpa.23290

M3 - Article

C2 - 28832922

AN - SCOPUS:85027516282

JO - American Journal of Physical Anthropology

JF - American Journal of Physical Anthropology

SN - 0002-9483

ER -