Abstract
In this study, we examine whether corrections made during an ongoing movement are differentially affected by left hemisphere damage (LHD) and right hemisphere damage (RHD). Our hypothesis of motor lateralization proposes that control mechanisms specialized to the right hemisphere rely largely on online processes, while the left hemisphere primarily utilizes predictive mechanisms to specify optimal coordination patterns. We therefore predict that RHD, but not LHD, should impair online correction when task goals are unexpectedly changed. Fourteen stroke subjects (7 LHD, 7 RHD) and 14 healthy controls reached to 1 of the 3 targets that unexpectedly "jumped" during movement onset. RHD subjects showed a considerable delay in initiating the corrective response relative to controls and LHD subjects. However, both stroke groups made large final position errors on the target jump trials. Position deficits following LHD were associated with poor intersegmental coordination, while RHD subjects had difficulty terminating their movements appropriately. These findings confirm that RHD, but not LHD, produces a deficit in the timing of online corrections and also indicate that both stroke groups show position deficits that are related to the specialization of their damaged hemisphere. Further research is needed to identify specific neural circuits within each hemisphere critical for these processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1407-1419 |
| Number of pages | 13 |
| Journal | Cerebral Cortex |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2012 |
| Externally published | Yes |
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Keywords
- lateralization
- motor control
- reaching
- stroke
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
Cite this
Hemispheric specialization for movement control produces dissociable differences in online corrections after stroke. / Schaefer, Sydney; Mutha, Pratik K.; Haaland, Kathleen Y.; Sainburg, Robert L.
In: Cerebral Cortex, Vol. 22, No. 6, 06.2012, p. 1407-1419.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemispheric specialization for movement control produces dissociable differences in online corrections after stroke
AU - Schaefer, Sydney
AU - Mutha, Pratik K.
AU - Haaland, Kathleen Y.
AU - Sainburg, Robert L.
PY - 2012/6
Y1 - 2012/6
N2 - In this study, we examine whether corrections made during an ongoing movement are differentially affected by left hemisphere damage (LHD) and right hemisphere damage (RHD). Our hypothesis of motor lateralization proposes that control mechanisms specialized to the right hemisphere rely largely on online processes, while the left hemisphere primarily utilizes predictive mechanisms to specify optimal coordination patterns. We therefore predict that RHD, but not LHD, should impair online correction when task goals are unexpectedly changed. Fourteen stroke subjects (7 LHD, 7 RHD) and 14 healthy controls reached to 1 of the 3 targets that unexpectedly "jumped" during movement onset. RHD subjects showed a considerable delay in initiating the corrective response relative to controls and LHD subjects. However, both stroke groups made large final position errors on the target jump trials. Position deficits following LHD were associated with poor intersegmental coordination, while RHD subjects had difficulty terminating their movements appropriately. These findings confirm that RHD, but not LHD, produces a deficit in the timing of online corrections and also indicate that both stroke groups show position deficits that are related to the specialization of their damaged hemisphere. Further research is needed to identify specific neural circuits within each hemisphere critical for these processes.
AB - In this study, we examine whether corrections made during an ongoing movement are differentially affected by left hemisphere damage (LHD) and right hemisphere damage (RHD). Our hypothesis of motor lateralization proposes that control mechanisms specialized to the right hemisphere rely largely on online processes, while the left hemisphere primarily utilizes predictive mechanisms to specify optimal coordination patterns. We therefore predict that RHD, but not LHD, should impair online correction when task goals are unexpectedly changed. Fourteen stroke subjects (7 LHD, 7 RHD) and 14 healthy controls reached to 1 of the 3 targets that unexpectedly "jumped" during movement onset. RHD subjects showed a considerable delay in initiating the corrective response relative to controls and LHD subjects. However, both stroke groups made large final position errors on the target jump trials. Position deficits following LHD were associated with poor intersegmental coordination, while RHD subjects had difficulty terminating their movements appropriately. These findings confirm that RHD, but not LHD, produces a deficit in the timing of online corrections and also indicate that both stroke groups show position deficits that are related to the specialization of their damaged hemisphere. Further research is needed to identify specific neural circuits within each hemisphere critical for these processes.
KW - lateralization
KW - motor control
KW - reaching
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84861565985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861565985&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhr237
DO - 10.1093/cercor/bhr237
M3 - Article
VL - 22
SP - 1407
EP - 1419
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 6
ER -