Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma

M. V. Agrez, R. E. Wharen, R. E. Anderson, E. R. Laws, D. M. Ilstrup, D. A. Cortese, R. G. Shorter, M. M. Lieber

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The selective affinity of hematoporphyrin derivative (HpD) for dimethyl‐hydrazine‐induced colorectal malignancies in mice was evaluated both visually and by a quantitative microfluorescent photometric technique. A significant corelation was found between higher concentrations of HpD in colon biopsies determined by microfluorescence spectroscopy and the presence of carcinoma cells in these biopsies as identified by histologic examination. Visual inspection of the gross fluorescence of tumor‐bearing colons in this experimental model, however, was not helpful in differentiating malignant from nonmalignant tissue. The implications of this study regarding the clinical application of HpD tumor fluorescence for the detection of colorectal carcinoma are discussed.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalJournal of Surgical Oncology
Volume24
Issue number3
DOIs
StatePublished - Nov 1983
Externally publishedYes

Keywords

  • colorectal carcinoma
  • hematoporphyrin derivative

ASJC Scopus subject areas

  • Surgery
  • Oncology

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  • Cite this

    Agrez, M. V., Wharen, R. E., Anderson, R. E., Laws, E. R., Ilstrup, D. M., Cortese, D. A., Shorter, R. G., & Lieber, M. M. (1983). Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma. Journal of Surgical Oncology, 24(3), 173-176. https://doi.org/10.1002/jso.2930240305