Helminth infection is associated with dampened cytokine responses to viral and bacterial stimulations in Tsimane forager-horticulturalists

India A. Schneider-Crease, Aaron D. Blackwell, Thomas S. Kraft, Melissa Emery Thompson, Ivan Maldonado Suarez, Daniel K. Cummings, Jonathan Stieglitz, Noah Snyder-Mackler, Michael Gurven, Hillard Kaplan, Benjamin C. Trumble

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Soil-transmitted helminths (STHs) and humans share long co-evolutionary histories over which STHs have evolved strategies to permit their persistence by downregulating host immunity. Understanding the interactions between STHs and other pathogens can inform our understanding of human evolution and contemporary disease patterns. Methodology: We worked with Tsimane forager-horticulturalists in the Bolivian Amazon, where STHs are prevalent. We tested whether STHs and eosinophil levels - likely indicative of infection in this population - are associated with dampened immune responses to in vitro stimulation with H1N1 and lipopolysaccharide (LPS) antigens. Whole blood samples (n = 179) were treated with H1N1 vaccine and LPS and assayed for 13 cytokines (INF-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, GM-CSF and TNF-α). We evaluated how STHs and eosinophil levels affected cytokine responses and T helper (Th) 1 and Th2-cytokine suite responses to stimulation. Results: Infection with Ascaris lumbricoides was significantly (P ≤ 0.05) associated with lower response of some cytokines to H1N1 and LPS in women. Eosinophils were significantly negatively associated with some cytokine responses to H1N1 and LPS, with the strongest effects in women, and associated with a reduced Th1- and Th2-cytokine response to H1N1 and LPS in women and men. Conclusions and implications: Consistent with the 'old friends' and hygiene hypotheses, we find that STHs were associated with dampened cytokine responses to certain viral and bacterial antigens. This suggests that STH infections may play an essential role in immune response regulation and that the lack of STH immune priming in industrialized populations may increase the risk of over-reactive immunity.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalEvolution, Medicine and Public Health
Volume9
Issue number1
DOIs
StatePublished - 2021

Keywords

  • bacteria
  • cytokine storms
  • eosinophilia
  • hygiene hypothesis
  • hypereosinophilia
  • immunomodulation
  • old friends hypothesis
  • soil-transmitted helminths
  • viruses

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Health, Toxicology and Mutagenesis

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