Heat shock effect upon dengue virus replication into U937 cells

Salvador Chavez-Salinas, Ivonne Ceballos-Olvera, Jorge Reyes-del Valle, Fernando Medina, Rosa M. del Angel

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26 Scopus citations


The molecules involved in dengue virus entry into human cells are currently unknown. We have previously shown that two surface heat shock proteins (Hsps), Hsp90 and Hsp70 are part of a receptor complex in monocytic cells. In the present report, the effect of heat shock (HS) on dengue virus infection is analyzed. We have documented a more than twofold increase in dengue virus infectivity after HS treatment in monocytic cells U937; this effect correlates mainly with an increase in viral entry due to a major presence of both Hsps on the surface of monocytic cells, particularly in membrane microdomains. Interestingly, since heat shock treatment at 6 h post-infection also increased viral yields, it is likely that HS also modulates positively dengue virus replication.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalVirus Research
Issue number1-2
Publication statusPublished - Dec 2008
Externally publishedYes



  • Dengue virus
  • Heat shock
  • Hsp
  • Lipid rafts
  • Replication

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Chavez-Salinas, S., Ceballos-Olvera, I., Reyes-del Valle, J., Medina, F., & del Angel, R. M. (2008). Heat shock effect upon dengue virus replication into U937 cells. Virus Research, 138(1-2), 111-118. https://doi.org/10.1016/j.virusres.2008.08.012