Heat index flow monitoring in capillaries with interferometric backscatter detection

Joseph C. StClaire, Mark Hayes

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Independent control of fluid is important for small volume fluid applications including separation science techniques and analytical microchip devices. To effectively control fluid, a monitoring system is necessary to ensure proper response to the control input. Proof of principle for a new online technique for flow monitoring is demonstrated here. It offers near real-time measurements of small-volume flows in a noninvasive, simple, and robust design. The measurement is accomplished by the introduction of a plug of heat into the fluid and detection of the time of its appearance a short distance downstream. Using heat indexing and laser induced interferometric backscatter as the detector, flow monitoring is demonstrated in 184-μm diameter capillary tubing over a range of 2-25 cm/s (500 nL/s to 7 mL/s.).

Original languageEnglish (US)
Pages (from-to)4726-4730
Number of pages5
JournalAnalytical chemistry
Volume72
Issue number19
DOIs
StatePublished - Oct 1 2000

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ASJC Scopus subject areas

  • Analytical Chemistry

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