Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene

Elizabeth A. Jacobsen, Olga Ananieva, Matthew L. Brown, Yung Chang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The nonreceptor tyrosine kinase, encoded by the v-Abl oncogene of Abelson murine leukemia virus induces transformation of progenitor B cells. The v-Abl oncogene promotes cell cycle progression and inhibits pre-B cell differentiation. The temperature-sensitive form of Abelson murine leukemia virus offers a reversible model to study the role of v-Abl in regulating growth and differentiation. Inactivation of v-Abl elevates p27 and Foxo3a levels and activates N-κB/Rel, which leads to G1 arrest and induction of Ig L chain gene rearrangement, respectively. In turn, v-Abl reactivation reduces p27 and Foxo3a levels, thus permitting G1-arrested cells to reenter the cell cycle. However, the cell lines derived from SCID mice that are defective in the catalytic subunit of DNA-dependent protein kinase retain elevated levels of p27 and Foxo3a proteins despite reactivation of v-Abl. Consequently, these cells are locked in the G1 phase for an extended period of time. The few cells that manage to bypass the G1 arrest become tumorigenic and fail to undergo pre-B cell differentiation induced by v-Abl inactivation. Deregulation of p27, Foxo3a, c-myc, and NF-κB/Rel was found to be associated with the malignant transformation of SCID temperature-sensitive form of Abelson murine leukemia virus pre-B cells.

Original languageEnglish (US)
Pages (from-to)6831-6838
Number of pages8
JournalJournal of Immunology
Volume176
Issue number11
StatePublished - Jun 1 2006

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abl Genes
Abelson murine leukemia virus
B-Lymphoid Precursor Cells
Growth
Cell Differentiation
Cell Cycle
DNA-Activated Protein Kinase
Catalytic DNA
Temperature
SCID Mice
Gene Rearrangement
G1 Phase
Protein-Tyrosine Kinases
Catalytic Domain
Cell Line
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene. / Jacobsen, Elizabeth A.; Ananieva, Olga; Brown, Matthew L.; Chang, Yung.

In: Journal of Immunology, Vol. 176, No. 11, 01.06.2006, p. 6831-6838.

Research output: Contribution to journalArticle

Jacobsen, Elizabeth A. ; Ananieva, Olga ; Brown, Matthew L. ; Chang, Yung. / Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene. In: Journal of Immunology. 2006 ; Vol. 176, No. 11. pp. 6831-6838.
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