Abstract

OBJECTIVE - In adults, the shape of the glucose response during an oral glucose tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described the utility of this indicator in younger populations. The purpose of this study was to compare type 2 diabetes risk factors in Latino adolescents characterized by either a monophasic or biphasic glucose response during an OGTT. RESEARCH DESIGN AND METHODS - A total of 156 nondiabetic Latino adolescents completed a 2-h OGTT. Monophasic and biphasic groups were compared for the following type 2 diabetes risk factors: fasting and 2-h glucose, HbA1c, glucose area under the curve (AUC), insulin sensitivity (Matsuda index), insulin secretion (insulinogenic index), and β-cell function as measured by the disposition index (insulin sensitivity x insulin secretion). RESULTS - Of the participants, 107 youth were categorized as monophasic and 49 were biphasic. Compared with the monophasic group, participants with a biphasic response exhibited lower HbA1c (5.4 6 0.3 vs. 5.6 ± 0.3%, P , 0.01) and lower glucose AUC (14,205 ± 2,382 vs. 16,230 ± 2,537 mg·dL-1·h -1, P , 0.001) with higher insulin sensitivity (5.4 ± 3.2 vs. 4.6 ± 3.4, P # 0.05), higher insulin secretion (2.1 ± 1.3 vs. 1.8 ± 1.3, P = 0.05), and better β-cell function (10.3 ± 7.8 vs. 6.0 ± 3.6, P < 0.001). Differences persisted after adjusting for age, sex, and BMI. CONCLUSIONS - These data suggest that the glycemic response to an OGTT may differentiate risk for type 2 diabetes in youth. This responsemay be an early marker of type 2 diabetes risk among high-risk youth.

Original languageEnglish (US)
Pages (from-to)1925-1930
Number of pages6
JournalDiabetes Care
Volume35
Issue number9
DOIs
StatePublished - Sep 2012

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Hispanic Americans
Type 2 Diabetes Mellitus
Glucose Tolerance Test
Glucose
Insulin Resistance
Insulin
Area Under Curve
Fasting
Research Design
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Glucose response curve and type 2 diabetes risk in latino adolescents. / Kim, Joon Young; Mandarino, Lawrence J.; Coletta, Dawn K.; Shaibi, Gabriel.

In: Diabetes Care, Vol. 35, No. 9, 09.2012, p. 1925-1930.

Research output: Contribution to journalArticle

Kim, Joon Young ; Mandarino, Lawrence J. ; Coletta, Dawn K. ; Shaibi, Gabriel. / Glucose response curve and type 2 diabetes risk in latino adolescents. In: Diabetes Care. 2012 ; Vol. 35, No. 9. pp. 1925-1930.
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abstract = "OBJECTIVE - In adults, the shape of the glucose response during an oral glucose tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described the utility of this indicator in younger populations. The purpose of this study was to compare type 2 diabetes risk factors in Latino adolescents characterized by either a monophasic or biphasic glucose response during an OGTT. RESEARCH DESIGN AND METHODS - A total of 156 nondiabetic Latino adolescents completed a 2-h OGTT. Monophasic and biphasic groups were compared for the following type 2 diabetes risk factors: fasting and 2-h glucose, HbA1c, glucose area under the curve (AUC), insulin sensitivity (Matsuda index), insulin secretion (insulinogenic index), and β-cell function as measured by the disposition index (insulin sensitivity x insulin secretion). RESULTS - Of the participants, 107 youth were categorized as monophasic and 49 were biphasic. Compared with the monophasic group, participants with a biphasic response exhibited lower HbA1c (5.4 6 0.3 vs. 5.6 ± 0.3{\%}, P , 0.01) and lower glucose AUC (14,205 ± 2,382 vs. 16,230 ± 2,537 mg·dL-1·h -1, P , 0.001) with higher insulin sensitivity (5.4 ± 3.2 vs. 4.6 ± 3.4, P # 0.05), higher insulin secretion (2.1 ± 1.3 vs. 1.8 ± 1.3, P = 0.05), and better β-cell function (10.3 ± 7.8 vs. 6.0 ± 3.6, P < 0.001). Differences persisted after adjusting for age, sex, and BMI. CONCLUSIONS - These data suggest that the glycemic response to an OGTT may differentiate risk for type 2 diabetes in youth. This responsemay be an early marker of type 2 diabetes risk among high-risk youth.",
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AU - Kim, Joon Young

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AU - Coletta, Dawn K.

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N2 - OBJECTIVE - In adults, the shape of the glucose response during an oral glucose tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described the utility of this indicator in younger populations. The purpose of this study was to compare type 2 diabetes risk factors in Latino adolescents characterized by either a monophasic or biphasic glucose response during an OGTT. RESEARCH DESIGN AND METHODS - A total of 156 nondiabetic Latino adolescents completed a 2-h OGTT. Monophasic and biphasic groups were compared for the following type 2 diabetes risk factors: fasting and 2-h glucose, HbA1c, glucose area under the curve (AUC), insulin sensitivity (Matsuda index), insulin secretion (insulinogenic index), and β-cell function as measured by the disposition index (insulin sensitivity x insulin secretion). RESULTS - Of the participants, 107 youth were categorized as monophasic and 49 were biphasic. Compared with the monophasic group, participants with a biphasic response exhibited lower HbA1c (5.4 6 0.3 vs. 5.6 ± 0.3%, P , 0.01) and lower glucose AUC (14,205 ± 2,382 vs. 16,230 ± 2,537 mg·dL-1·h -1, P , 0.001) with higher insulin sensitivity (5.4 ± 3.2 vs. 4.6 ± 3.4, P # 0.05), higher insulin secretion (2.1 ± 1.3 vs. 1.8 ± 1.3, P = 0.05), and better β-cell function (10.3 ± 7.8 vs. 6.0 ± 3.6, P < 0.001). Differences persisted after adjusting for age, sex, and BMI. CONCLUSIONS - These data suggest that the glycemic response to an OGTT may differentiate risk for type 2 diabetes in youth. This responsemay be an early marker of type 2 diabetes risk among high-risk youth.

AB - OBJECTIVE - In adults, the shape of the glucose response during an oral glucose tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described the utility of this indicator in younger populations. The purpose of this study was to compare type 2 diabetes risk factors in Latino adolescents characterized by either a monophasic or biphasic glucose response during an OGTT. RESEARCH DESIGN AND METHODS - A total of 156 nondiabetic Latino adolescents completed a 2-h OGTT. Monophasic and biphasic groups were compared for the following type 2 diabetes risk factors: fasting and 2-h glucose, HbA1c, glucose area under the curve (AUC), insulin sensitivity (Matsuda index), insulin secretion (insulinogenic index), and β-cell function as measured by the disposition index (insulin sensitivity x insulin secretion). RESULTS - Of the participants, 107 youth were categorized as monophasic and 49 were biphasic. Compared with the monophasic group, participants with a biphasic response exhibited lower HbA1c (5.4 6 0.3 vs. 5.6 ± 0.3%, P , 0.01) and lower glucose AUC (14,205 ± 2,382 vs. 16,230 ± 2,537 mg·dL-1·h -1, P , 0.001) with higher insulin sensitivity (5.4 ± 3.2 vs. 4.6 ± 3.4, P # 0.05), higher insulin secretion (2.1 ± 1.3 vs. 1.8 ± 1.3, P = 0.05), and better β-cell function (10.3 ± 7.8 vs. 6.0 ± 3.6, P < 0.001). Differences persisted after adjusting for age, sex, and BMI. CONCLUSIONS - These data suggest that the glycemic response to an OGTT may differentiate risk for type 2 diabetes in youth. This responsemay be an early marker of type 2 diabetes risk among high-risk youth.

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