Abstract
In this paper, the authors first show that if R 0 ≤ 1, the infection free steady state is globally attractive by using approaches different from those given by Min, et al.(2008). Then the authors prove that if R 0 > 1, the endemic steady state is also globally attractive. Finally, based on a patient's clinical HBV DNA data of anti-HBV infection with drug lamivudine, the authors establish an ABVIM. The numerical simulations of the ABVIM are good in agreement with the clinical data.
Original language | English (US) |
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Pages (from-to) | 1221-1230 |
Number of pages | 10 |
Journal | Journal of Systems Science and Complexity |
Volume | 23 |
Issue number | 6 |
DOIs | |
State | Published - Dec 27 2010 |
Keywords
- Basic infection reproduction number
- HBV infection
- clinical data simulation
- equilibrium point
- global stability
ASJC Scopus subject areas
- Computer Science (miscellaneous)
- Information Systems