Girls’ pubertal development is associated with white matter microstructure in late adolescence

Rajpreet Chahal, Veronika Vilgis, Kevin Grimm, Alison E. Hipwell, Erika E. Forbes, Kate Keenan, Amanda E. Guyer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Patterns of pubertal maturation have been linked to vulnerability for emotion dysregulation disorders in girls, as well as white matter (WM) development, suggestive of a potential mechanism between pubertal maturation and emotional health. Because pubertal processes begin at varying ages (i.e., status, timing) and proceed at varying rates (i.e., tempo), identifying individual differences in the pubertal course associated with subsequent WM microstructure development may reveal clues about neurobiological mechanisms of girls’ emotional well-being. In a prospective cohort study of 107 girls, we examined associations between pubertal status at age 9, pubertal timing and tempo from ages 9–15, and WM microstructure at age 19. Tract-based spatial statistics revealed that girls with more advanced pubertal status at age 9, specific to gonadal-related physical changes, had higher fractional anisotropy, and lower mean diffusivity (MD) and radial diffusivity in tracts relevant to cognitive control and emotion regulation (e.g., the superior longitudinal fasciculus, external capsule, and uncinate fasciculus). Additionally, girls with earlier pubertal timing showed lower MD in the left anterior cingulum bundle. Tempo was unrelated to WM measures. These findings implicate specific aspects of pubertal maturation in subsequent neural signatures, suggesting possible neuroendocrine mechanisms relevant to emotional development. Future work incorporating longitudinal neuroimaging in parallel with pubertal measures may contribute to the understanding of individual variation in pubertal course and WM development.

Original languageEnglish (US)
Pages (from-to)659-669
Number of pages11
JournalNeuroImage
Volume181
DOIs
StatePublished - Nov 1 2018

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Emotions
Anisotropy
Individuality
Neuroimaging
Cohort Studies
White Matter
Prospective Studies
Health
External Capsule

Keywords

  • Adolescence
  • DTI
  • Puberty
  • White matter

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Girls’ pubertal development is associated with white matter microstructure in late adolescence. / Chahal, Rajpreet; Vilgis, Veronika; Grimm, Kevin; Hipwell, Alison E.; Forbes, Erika E.; Keenan, Kate; Guyer, Amanda E.

In: NeuroImage, Vol. 181, 01.11.2018, p. 659-669.

Research output: Contribution to journalArticle

Chahal, Rajpreet ; Vilgis, Veronika ; Grimm, Kevin ; Hipwell, Alison E. ; Forbes, Erika E. ; Keenan, Kate ; Guyer, Amanda E. / Girls’ pubertal development is associated with white matter microstructure in late adolescence. In: NeuroImage. 2018 ; Vol. 181. pp. 659-669.
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