Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: Evidence for a histogenetic relationship and mesenchymal differentiation

Kent B. Lewandrowski, Lynn Weston, G. Richard Dickersin, David W. Rattner, Carolyn Compton

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We describe a giant cell tumor of the pancreas composed of a mixture of osteoclastic and pleomorphic cell types. This rare tumor had a unique immunohistochemical profile. Both types of tumor giant cells stained for vimentin, α-1-antitrypsin, α-1-antichymotrypsin, synaptophysin, muscle actin, and neuron-specific enolase, but not for epithelial markers. Electron microscopy showed cells which resembled primitive fibroblasts and osteoclasts with no epithelial features. These findings are most consistent with mesenchymal differentiation. The extensive homologies in immunohistochemical staining of both osteoclastic and pleomorphic giant cells in this case indicates that these cells are histogenetically related.

Original languageEnglish (US)
Pages (from-to)1184-1187
Number of pages4
JournalHuman Pathology
Volume21
Issue number11
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Giant Cell Tumors
Pancreas
Synaptophysin
Phosphopyruvate Hydratase
Vimentin
Osteoclasts
Giant Cells
Actins
Electron Microscopy
Fibroblasts
Staining and Labeling
Muscles
Neoplasms

Keywords

  • giant cell tumor
  • osteoclastic type
  • pancreas
  • pleomorphic type
  • sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type : Evidence for a histogenetic relationship and mesenchymal differentiation. / Lewandrowski, Kent B.; Weston, Lynn; Richard Dickersin, G.; Rattner, David W.; Compton, Carolyn.

In: Human Pathology, Vol. 21, No. 11, 1990, p. 1184-1187.

Research output: Contribution to journalArticle

Lewandrowski, Kent B. ; Weston, Lynn ; Richard Dickersin, G. ; Rattner, David W. ; Compton, Carolyn. / Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type : Evidence for a histogenetic relationship and mesenchymal differentiation. In: Human Pathology. 1990 ; Vol. 21, No. 11. pp. 1184-1187.
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