GFAP inflammatory response to dextran-coated silicon electrodes

Matthew M. Holecko, Stephen Massia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent advances in three-dimensional, confocal imaging techniques and image analysis software allow for previously unattainable measurements in the neural environment. Specifically, relative quantitative measurements of the amount of glial fibrillary acidic protein (GFAP) surrounding a neural implant can be determined. In this study, dextran coatings have been applied to silicon neural implants. Dextran coatings have been shown to limit non-specific cell adhesion in vitro. Thus, it is believed that these coatings will limit the amount of gliosis surrounding a neural implant and ultimately improve signal-to-noise ratio. To test this hypothesis, Sprague-Dawley rats were implanted with both dextran-coated and non-dextran-coated silicon electrodes. Using immunohistochemical staining in conjunction with confocal imaging and image analysis techniques, the differences in GFAP upregulation between dextran-coated and non-treated silicon neural implants were investigated.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages1832-1833
Number of pages2
Volume3
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Other

OtherProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
CountryUnited States
CityHouston, TX
Period10/23/0210/26/02

Keywords

  • Astrocyte
  • Confocal
  • GFAP
  • Gliosis
  • Imaging
  • Neural

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Holecko, M. M., & Massia, S. (2002). GFAP inflammatory response to dextran-coated silicon electrodes. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 3, pp. 1832-1833)