TY - GEN
T1 - Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures
AU - Nikkhah, Mehdi
AU - Strobl, Jeannine S.
AU - Agah, Masoud
PY - 2007/12/1
Y1 - 2007/12/1
N2 - understanding the relationship between the cell and the substrate in microenvironments is a critical issue in cell biology research. In this paper, we report the response of HS68 normal human foreskin fibroblast cells to three-dimensional silicon microstructures, which are designed and fabricated using a single-mask fabrication technique. Our device composed of a network of microfluidic channels and microchambers with different widths and depths. Our results show that human fibroblast cells do not tend to go inside microchambers having isotropic cross sections and curved sidewalls, and moreover, their growth rate decreases as the depth increases. The growth rate decline has been utilized as a new method to create patterned cell culture.
AB - understanding the relationship between the cell and the substrate in microenvironments is a critical issue in cell biology research. In this paper, we report the response of HS68 normal human foreskin fibroblast cells to three-dimensional silicon microstructures, which are designed and fabricated using a single-mask fabrication technique. Our device composed of a network of microfluidic channels and microchambers with different widths and depths. Our results show that human fibroblast cells do not tend to go inside microchambers having isotropic cross sections and curved sidewalls, and moreover, their growth rate decreases as the depth increases. The growth rate decline has been utilized as a new method to create patterned cell culture.
UR - http://www.scopus.com/inward/record.url?scp=57649228982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57649228982&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2007.4353735
DO - 10.1109/IEMBS.2007.4353735
M3 - Conference contribution
AN - SCOPUS:57649228982
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 6077
EP - 6080
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -