Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures

Mehdi Nikkhah, Jeannine S. Strobl, Masoud Agah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

understanding the relationship between the cell and the substrate in microenvironments is a critical issue in cell biology research. In this paper, we report the response of HS68 normal human foreskin fibroblast cells to three-dimensional silicon microstructures, which are designed and fabricated using a single-mask fabrication technique. Our device composed of a network of microfluidic channels and microchambers with different widths and depths. Our results show that human fibroblast cells do not tend to go inside microchambers having isotropic cross sections and curved sidewalls, and moreover, their growth rate decreases as the depth increases. The growth rate decline has been utilized as a new method to create patterned cell culture.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages6077-6080
Number of pages4
DOIs
StatePublished - 2007
Externally publishedYes
Event29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France
Duration: Aug 23 2007Aug 26 2007

Other

Other29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
CountryFrance
CityLyon
Period8/23/078/26/07

Fingerprint

Fibroblasts
Cells
Cytology
Silicon
Microstructure
Geometry
Cell culture
Microfluidics
Masks
Fabrication
Substrates

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Nikkhah, M., Strobl, J. S., & Agah, M. (2007). Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 6077-6080). [4353735] https://doi.org/10.1109/IEMBS.2007.4353735

Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures. / Nikkhah, Mehdi; Strobl, Jeannine S.; Agah, Masoud.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 6077-6080 4353735.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nikkhah, M, Strobl, JS & Agah, M 2007, Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4353735, pp. 6077-6080, 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, France, 8/23/07. https://doi.org/10.1109/IEMBS.2007.4353735
Nikkhah M, Strobl JS, Agah M. Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 6077-6080. 4353735 https://doi.org/10.1109/IEMBS.2007.4353735
Nikkhah, Mehdi ; Strobl, Jeannine S. ; Agah, Masoud. / Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. pp. 6077-6080
@inproceedings{6108960295b4485bbf6fb58e3692be6c,
title = "Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures",
abstract = "understanding the relationship between the cell and the substrate in microenvironments is a critical issue in cell biology research. In this paper, we report the response of HS68 normal human foreskin fibroblast cells to three-dimensional silicon microstructures, which are designed and fabricated using a single-mask fabrication technique. Our device composed of a network of microfluidic channels and microchambers with different widths and depths. Our results show that human fibroblast cells do not tend to go inside microchambers having isotropic cross sections and curved sidewalls, and moreover, their growth rate decreases as the depth increases. The growth rate decline has been utilized as a new method to create patterned cell culture.",
author = "Mehdi Nikkhah and Strobl, {Jeannine S.} and Masoud Agah",
year = "2007",
doi = "10.1109/IEMBS.2007.4353735",
language = "English (US)",
isbn = "1424407885",
pages = "6077--6080",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

}

TY - GEN

T1 - Geometry-dependent behavior of fibroblast cells in three-dimensional silicon microstructures

AU - Nikkhah, Mehdi

AU - Strobl, Jeannine S.

AU - Agah, Masoud

PY - 2007

Y1 - 2007

N2 - understanding the relationship between the cell and the substrate in microenvironments is a critical issue in cell biology research. In this paper, we report the response of HS68 normal human foreskin fibroblast cells to three-dimensional silicon microstructures, which are designed and fabricated using a single-mask fabrication technique. Our device composed of a network of microfluidic channels and microchambers with different widths and depths. Our results show that human fibroblast cells do not tend to go inside microchambers having isotropic cross sections and curved sidewalls, and moreover, their growth rate decreases as the depth increases. The growth rate decline has been utilized as a new method to create patterned cell culture.

AB - understanding the relationship between the cell and the substrate in microenvironments is a critical issue in cell biology research. In this paper, we report the response of HS68 normal human foreskin fibroblast cells to three-dimensional silicon microstructures, which are designed and fabricated using a single-mask fabrication technique. Our device composed of a network of microfluidic channels and microchambers with different widths and depths. Our results show that human fibroblast cells do not tend to go inside microchambers having isotropic cross sections and curved sidewalls, and moreover, their growth rate decreases as the depth increases. The growth rate decline has been utilized as a new method to create patterned cell culture.

UR - http://www.scopus.com/inward/record.url?scp=57649228982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57649228982&partnerID=8YFLogxK

U2 - 10.1109/IEMBS.2007.4353735

DO - 10.1109/IEMBS.2007.4353735

M3 - Conference contribution

SN - 1424407885

SN - 9781424407880

SP - 6077

EP - 6080

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ER -