Geographic inequities in liver allograft supply and demand: Does it affect patient outcomes?

Abbas Rana, Bruce Kaplan, Irbaz B. Riaz, Marian Porubsky, Shahid Habib, Horacio Rilo, Angelika C. Gruessner, Rainer W G Gruessner

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background Significant geographic inequities mar the distribution of liver allografts for transplantation. Methods We analyzed the effect of geographic inequities on patient outcomes. During our study period (January 1 through December 31, 2010), 11,244 adult candidates were listed for liver transplantation: 5,285 adult liver allografts became available, and 5,471 adult recipients underwent transplantation. We obtained population data from the 2010 United States Census. To determine the effect of regional supply and demand disparities on patient outcomes, we performed linear regression and multivariate Cox regression analyses. Results Our proposed disparity metric, the ratio of listed candidates to liver allografts available varied from 1.3 (region 11) to 3.4 (region 1). When that ratio was used as the explanatory variable, the R2 values for outcome measures were as follows: 1-year waitlist mortality, 0.23 and 1-year posttransplant survival, 0.27. According to our multivariate analysis, the ratio of listed candidates to liver allografts available had a significant effect on waitlist survival (hazards ratio, 1.21; 95% confidence interval, 1.04-1.40) but was not a significant risk factor for posttransplant survival. Conclusion We found significant differences in liver allograft supply and demand - but these differences had only a modest effect on patient outcomes. Redistricting and allocation-sharing schemes should seek to equalize regional supply and demand rather than attempting to equalize patient outcomes.

Original languageEnglish (US)
Pages (from-to)515-520
Number of pages6
JournalTransplantation
Volume99
Issue number3
DOIs
StatePublished - Mar 4 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Transplantation

Cite this

Rana, A., Kaplan, B., Riaz, I. B., Porubsky, M., Habib, S., Rilo, H., Gruessner, A. C., & Gruessner, R. W. G. (2015). Geographic inequities in liver allograft supply and demand: Does it affect patient outcomes? Transplantation, 99(3), 515-520. https://doi.org/10.1097/TP.0000000000000372