TY - JOUR
T1 - Genomic insights into the host specific adaptation of the Pneumocystis genus
AU - Cissé, Ousmane H.
AU - Ma, Liang
AU - Dekker, John P.
AU - Khil, Pavel P.
AU - Youn, Jung Ho
AU - Brenchley, Jason M.
AU - Blair, Robert
AU - Pahar, Bapi
AU - Chabé, Magali
AU - Van Rompay, Koen K.A.
AU - Keesler, Rebekah
AU - Sukura, Antti
AU - Hirsch, Vanessa
AU - Kutty, Geetha
AU - Liu, Yueqin
AU - Peng, Li
AU - Chen, Jie
AU - Song, Jun
AU - Weissenbacher-Lang, Christiane
AU - Xu, Jie
AU - Upham, Nathan S.
AU - Stajich, Jason E.
AU - Cuomo, Christina A.
AU - Cushion, Melanie T.
AU - Kovacs, Joseph A.
PY - 2021/3/8
Y1 - 2021/3/8
N2 - Pneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of species infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans.
AB - Pneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of species infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans.
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U2 - 10.1038/s42003-021-01799-7
DO - 10.1038/s42003-021-01799-7
M3 - Article
C2 - 33686174
AN - SCOPUS:85102712174
SN - 2399-3642
VL - 4
SP - 305
JO - Communications Biology
JF - Communications Biology
IS - 1
ER -